Persistent follicular granulosa cell senescence and apoptosis induced by methotrexate leading to oocyte dysfunction and aberrant embryo development

Evidence from clinical cases indicates an association between the low success rate of in vitro fertilization (IVF) and ovarian injury due to previous methotrexate (MTX) administration. Therefore, it is necessary to develop and propose reasonable clinical drug guidelines to improve the quality of ooc...

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Detalles Bibliográficos
Autores principales: Fu, Jingbo, Liu, Yang, Wang, Chen, Zhang, Hongxia, Yu, Bin, Wang, Ye, Zhu, Haiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504813/
https://www.ncbi.nlm.nih.gov/pubmed/33982403
http://dx.doi.org/10.1111/cts.13068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504813/
https://www.ncbi.nlm.nih.gov/pubmed/33982403
http://dx.doi.org/10.1111/cts.13068

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