Particle size affects pharmacokinetics of milled oxycodone hydrochloride tablet products following nasal insufflation in nondependent, recreational opioid users

This study assessed the impact of product particle sizes (fine: 106–500 µm; coarse: 500–1000 µm) on oxycodone pharmacokinetics (PK) following nasal insufflation of milled oxycodone extended‐release (ER) abuse‐deterrent (AD) tablets using immediate‐release (IR) non‐AD product as reference. Additional...

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Detalles Bibliográficos
Autores principales: Raofi, Saeid, Kinjo, Minori, Sun, Dajun, Li, Zhichuan, Boyce, Heather, Natarajan, Karthika, Frost, Mitchell, Zhao, Liang, Luke, Markham, Lionberger, Robert, Kelsh, Debra, Kim, Myong‐Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504826/
https://www.ncbi.nlm.nih.gov/pubmed/33982418
http://dx.doi.org/10.1111/cts.13053

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