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Midlife and late‐life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study
AIMS/INTRODUCTION: To investigate the association between midlife or late‐life diabetes and the development of sarcopenia in an older Japanese population. MATERIALS AND METHODS: A total of 824 Japanese residents aged 65 to 84 years without sarcopenia were followed up from 2012 to 2017. Sarcopenia wa...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504915/ https://www.ncbi.nlm.nih.gov/pubmed/33742564 http://dx.doi.org/10.1111/jdi.13550 |
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author | Nakamura, Kimitaka Yoshida, Daigo Honda, Takanori Hata, Jun Shibata, Mao Hirakawa, Yoichiro Furuta, Yoshihiko Kishimoto, Hiro Ohara, Tomoyuki Chen, Sanmei Kitazono, Takanari Nakashima, Yasuharu Ninomiya, Toshiharu |
author_facet | Nakamura, Kimitaka Yoshida, Daigo Honda, Takanori Hata, Jun Shibata, Mao Hirakawa, Yoichiro Furuta, Yoshihiko Kishimoto, Hiro Ohara, Tomoyuki Chen, Sanmei Kitazono, Takanari Nakashima, Yasuharu Ninomiya, Toshiharu |
author_sort | Nakamura, Kimitaka |
collection | PubMed |
description | AIMS/INTRODUCTION: To investigate the association between midlife or late‐life diabetes and the development of sarcopenia in an older Japanese population. MATERIALS AND METHODS: A total of 824 Japanese residents aged 65 to 84 years without sarcopenia were followed up from 2012 to 2017. Sarcopenia was determined following the Asian Working Group for Sarcopenia definition. The time of diabetes diagnosis was classified as midlife or late‐life diabetes by the age at first diagnosis of diabetes (< 65 or ≥ 65 years) based on annual health checkups data over the past 24 years. The duration of diabetes was categorized into three groups of < 10, 10–15, and > 15 years. The odds ratios of incident sarcopenia according to the diabetic status were estimated using a logistic regression analysis. RESULTS: During follow‐up, 47 subjects developed sarcopenia. The multivariable‐adjusted odds ratio for incident sarcopenia was significantly greater in subjects with diabetes at baseline than in those without it (odds ratio 2.51, 95% confidence interval 1.26–5.00). Subjects with midlife diabetes had a significantly greater risk of incident sarcopenia, whereas no significant association between late‐life diabetes and incident sarcopenia was observed. With a longer duration of diabetes, the risk of incident sarcopenia increased significantly (P for trend = 0.002). CONCLUSIONS: The present study suggests that midlife diabetes and a longer duration of diabetes are significant risk factors for incident sarcopenia in the older population. Preventing diabetes in midlife may reduce the risk of the development of sarcopenia in later life. |
format | Online Article Text |
id | pubmed-8504915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85049152021-10-18 Midlife and late‐life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study Nakamura, Kimitaka Yoshida, Daigo Honda, Takanori Hata, Jun Shibata, Mao Hirakawa, Yoichiro Furuta, Yoshihiko Kishimoto, Hiro Ohara, Tomoyuki Chen, Sanmei Kitazono, Takanari Nakashima, Yasuharu Ninomiya, Toshiharu J Diabetes Investig Original Articles AIMS/INTRODUCTION: To investigate the association between midlife or late‐life diabetes and the development of sarcopenia in an older Japanese population. MATERIALS AND METHODS: A total of 824 Japanese residents aged 65 to 84 years without sarcopenia were followed up from 2012 to 2017. Sarcopenia was determined following the Asian Working Group for Sarcopenia definition. The time of diabetes diagnosis was classified as midlife or late‐life diabetes by the age at first diagnosis of diabetes (< 65 or ≥ 65 years) based on annual health checkups data over the past 24 years. The duration of diabetes was categorized into three groups of < 10, 10–15, and > 15 years. The odds ratios of incident sarcopenia according to the diabetic status were estimated using a logistic regression analysis. RESULTS: During follow‐up, 47 subjects developed sarcopenia. The multivariable‐adjusted odds ratio for incident sarcopenia was significantly greater in subjects with diabetes at baseline than in those without it (odds ratio 2.51, 95% confidence interval 1.26–5.00). Subjects with midlife diabetes had a significantly greater risk of incident sarcopenia, whereas no significant association between late‐life diabetes and incident sarcopenia was observed. With a longer duration of diabetes, the risk of incident sarcopenia increased significantly (P for trend = 0.002). CONCLUSIONS: The present study suggests that midlife diabetes and a longer duration of diabetes are significant risk factors for incident sarcopenia in the older population. Preventing diabetes in midlife may reduce the risk of the development of sarcopenia in later life. John Wiley and Sons Inc. 2021-05-04 2021-10 /pmc/articles/PMC8504915/ /pubmed/33742564 http://dx.doi.org/10.1111/jdi.13550 Text en © 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Nakamura, Kimitaka Yoshida, Daigo Honda, Takanori Hata, Jun Shibata, Mao Hirakawa, Yoichiro Furuta, Yoshihiko Kishimoto, Hiro Ohara, Tomoyuki Chen, Sanmei Kitazono, Takanari Nakashima, Yasuharu Ninomiya, Toshiharu Midlife and late‐life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study |
title | Midlife and late‐life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study |
title_full | Midlife and late‐life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study |
title_fullStr | Midlife and late‐life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study |
title_full_unstemmed | Midlife and late‐life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study |
title_short | Midlife and late‐life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study |
title_sort | midlife and late‐life diabetes and sarcopenia in a general older japanese population: the hisayama study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504915/ https://www.ncbi.nlm.nih.gov/pubmed/33742564 http://dx.doi.org/10.1111/jdi.13550 |
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