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The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma
PURPOSE: The aim of this research was to investigate the clinical significance of the expression of flap structure-specific endonuclease 1 (FEN1) in primary osteosarcoma. METHODS: The expression of FEN1 was detected by immunohistochemistry analysis. The association of the expression of FEN1 in osteo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504935/ https://www.ncbi.nlm.nih.gov/pubmed/34675615 http://dx.doi.org/10.2147/IJGM.S335817 |
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author | Zhong, Guangxian Wang, Yunqing Wei, Hongxiang Chen, Meifang Lin, Huangfeng Huang, Zhen Huang, Jinlong Wang, Shenglin Lin, Jianhua |
author_facet | Zhong, Guangxian Wang, Yunqing Wei, Hongxiang Chen, Meifang Lin, Huangfeng Huang, Zhen Huang, Jinlong Wang, Shenglin Lin, Jianhua |
author_sort | Zhong, Guangxian |
collection | PubMed |
description | PURPOSE: The aim of this research was to investigate the clinical significance of the expression of flap structure-specific endonuclease 1 (FEN1) in primary osteosarcoma. METHODS: The expression of FEN1 was detected by immunohistochemistry analysis. The association of the expression of FEN1 in osteosarcoma with clinicopathological parameters was analyzed by using χ(2) test or Fisher’s exact test. Survival analyses were performed by Kaplan–Meier method and Cox proportional hazards regression model. RESULTS: Of the 40 osteosarcoma patients, 19 (47.5%) patients presented with FEN1 high expression, while in the non-neoplastic bone specimens, the FEN1 high expression was observed in 10% (3/30), the positive expression rate in osteosarcoma patients was significantly higher than that of non-neoplastic bone specimens (P< 0.01). Univariate analysis indicated that the progression-free survival (PFS) and overall survival (OS) were correlated with the expression level of FEN1 (PFS, P < 0.001; OS, P = 0.002), Enneking staging (PFS, P = 0.026; OS, P = 0.044) and chemotherapy response (PFS, P = 0.019; OS, P = 0.031). Multivariate analysis demonstrated that FEN1 expression was an independent prognostic factor for the PFS (HR = 4.73, P = 0.002) and OS (HR = 4.01, P = 0.038) of osteosarcoma patients. CONCLUSION: This study showed that FEN1 was overexpressed in osteosarcoma patients and positively associated with poor prognosis of osteosarcoma patients. Further studies should focus on the relative mechanisms and the targeted FEN1 therapies for osteosarcoma. |
format | Online Article Text |
id | pubmed-8504935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-85049352021-10-20 The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma Zhong, Guangxian Wang, Yunqing Wei, Hongxiang Chen, Meifang Lin, Huangfeng Huang, Zhen Huang, Jinlong Wang, Shenglin Lin, Jianhua Int J Gen Med Original Research PURPOSE: The aim of this research was to investigate the clinical significance of the expression of flap structure-specific endonuclease 1 (FEN1) in primary osteosarcoma. METHODS: The expression of FEN1 was detected by immunohistochemistry analysis. The association of the expression of FEN1 in osteosarcoma with clinicopathological parameters was analyzed by using χ(2) test or Fisher’s exact test. Survival analyses were performed by Kaplan–Meier method and Cox proportional hazards regression model. RESULTS: Of the 40 osteosarcoma patients, 19 (47.5%) patients presented with FEN1 high expression, while in the non-neoplastic bone specimens, the FEN1 high expression was observed in 10% (3/30), the positive expression rate in osteosarcoma patients was significantly higher than that of non-neoplastic bone specimens (P< 0.01). Univariate analysis indicated that the progression-free survival (PFS) and overall survival (OS) were correlated with the expression level of FEN1 (PFS, P < 0.001; OS, P = 0.002), Enneking staging (PFS, P = 0.026; OS, P = 0.044) and chemotherapy response (PFS, P = 0.019; OS, P = 0.031). Multivariate analysis demonstrated that FEN1 expression was an independent prognostic factor for the PFS (HR = 4.73, P = 0.002) and OS (HR = 4.01, P = 0.038) of osteosarcoma patients. CONCLUSION: This study showed that FEN1 was overexpressed in osteosarcoma patients and positively associated with poor prognosis of osteosarcoma patients. Further studies should focus on the relative mechanisms and the targeted FEN1 therapies for osteosarcoma. Dove 2021-10-07 /pmc/articles/PMC8504935/ /pubmed/34675615 http://dx.doi.org/10.2147/IJGM.S335817 Text en © 2021 Zhong et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Zhong, Guangxian Wang, Yunqing Wei, Hongxiang Chen, Meifang Lin, Huangfeng Huang, Zhen Huang, Jinlong Wang, Shenglin Lin, Jianhua The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma |
title | The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma |
title_full | The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma |
title_fullStr | The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma |
title_full_unstemmed | The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma |
title_short | The Clinical Significance of the Expression of FEN1 in Primary Osteosarcoma |
title_sort | clinical significance of the expression of fen1 in primary osteosarcoma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504935/ https://www.ncbi.nlm.nih.gov/pubmed/34675615 http://dx.doi.org/10.2147/IJGM.S335817 |
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