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Structural variability and concerted motions of the T cell receptor – CD3 complex

We investigate the structural and orientational variability of the membrane-embedded T cell receptor (TCR) – CD3 complex in extensive atomistic molecular dynamics simulations based on the recent cryo-EM structure determined by Dong et al., 2019. We find that the TCR extracellular (EC) domain is high...

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Detalles Bibliográficos
Autores principales:	Pandey, Prithvi R, Różycki, Bartosz, Lipowsky, Reinhard, Weikl, Thomas R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504971/ https://www.ncbi.nlm.nih.gov/pubmed/34490842 http://dx.doi.org/10.7554/eLife.67195

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