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Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy

The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with...

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Autores principales: Muto, Momotaro, Nakata, Hirotaka, Ishigaki, Kenichi, Tachibana, Shion, Yoshida, Moe, Muto, Mizue, Yanagawa, Nobuyuki, Okumura, Toshikatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Gastric Cancer Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505119/
https://www.ncbi.nlm.nih.gov/pubmed/34691815
http://dx.doi.org/10.5230/jgc.2021.21.e24
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author Muto, Momotaro
Nakata, Hirotaka
Ishigaki, Kenichi
Tachibana, Shion
Yoshida, Moe
Muto, Mizue
Yanagawa, Nobuyuki
Okumura, Toshikatsu
author_facet Muto, Momotaro
Nakata, Hirotaka
Ishigaki, Kenichi
Tachibana, Shion
Yoshida, Moe
Muto, Mizue
Yanagawa, Nobuyuki
Okumura, Toshikatsu
author_sort Muto, Momotaro
collection PubMed
description The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with brain radiotherapy and anti-programmed death-1 (PD-1) therapy-induced abscopal effect. Although anti-PD-1 therapy alone could not prevent disease progression, the metastatic lesions in the brain and also in the abdominal lymph node showed a drastic response after brain radiotherapy and anti-PD-1 therapy. To our knowledge, this is the first reported case of successful treatment of advanced gastric cancer with multiple brain and abdominal lymph node metastases, possibly through anti-PD-1 therapy combined with brain radiotherapy-induced abscopal effect. We suggest that the combination of brain radiotherapy and anti-PD-1 therapy may be considered as a therapeutic option for advanced gastric cancer, especially when there is brain metastasis.
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spelling pubmed-85051192021-10-22 Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy Muto, Momotaro Nakata, Hirotaka Ishigaki, Kenichi Tachibana, Shion Yoshida, Moe Muto, Mizue Yanagawa, Nobuyuki Okumura, Toshikatsu J Gastric Cancer Case Report The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with brain radiotherapy and anti-programmed death-1 (PD-1) therapy-induced abscopal effect. Although anti-PD-1 therapy alone could not prevent disease progression, the metastatic lesions in the brain and also in the abdominal lymph node showed a drastic response after brain radiotherapy and anti-PD-1 therapy. To our knowledge, this is the first reported case of successful treatment of advanced gastric cancer with multiple brain and abdominal lymph node metastases, possibly through anti-PD-1 therapy combined with brain radiotherapy-induced abscopal effect. We suggest that the combination of brain radiotherapy and anti-PD-1 therapy may be considered as a therapeutic option for advanced gastric cancer, especially when there is brain metastasis. The Korean Gastric Cancer Association 2021-09 2021-08-24 /pmc/articles/PMC8505119/ /pubmed/34691815 http://dx.doi.org/10.5230/jgc.2021.21.e24 Text en Copyright © 2021. Korean Gastric Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Muto, Momotaro
Nakata, Hirotaka
Ishigaki, Kenichi
Tachibana, Shion
Yoshida, Moe
Muto, Mizue
Yanagawa, Nobuyuki
Okumura, Toshikatsu
Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy
title Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy
title_full Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy
title_fullStr Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy
title_full_unstemmed Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy
title_short Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy
title_sort successful treatment of advanced gastric cancer with brain metastases through an abscopal effect by radiation and immune checkpoint inhibitor therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505119/
https://www.ncbi.nlm.nih.gov/pubmed/34691815
http://dx.doi.org/10.5230/jgc.2021.21.e24
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