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Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration

Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were intro...

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Autores principales: Ahmed, Geraldine M., Abouauf, Eman A., AbuBakr, Nermeen, Fouad, Asmaa M., Dörfer, Christof E., Fawzy El-Sayed, Karim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505125/
https://www.ncbi.nlm.nih.gov/pubmed/34646323
http://dx.doi.org/10.1155/2021/8483668
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author Ahmed, Geraldine M.
Abouauf, Eman A.
AbuBakr, Nermeen
Fouad, Asmaa M.
Dörfer, Christof E.
Fawzy El-Sayed, Karim M.
author_facet Ahmed, Geraldine M.
Abouauf, Eman A.
AbuBakr, Nermeen
Fouad, Asmaa M.
Dörfer, Christof E.
Fawzy El-Sayed, Karim M.
author_sort Ahmed, Geraldine M.
collection PubMed
description Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were introduced for a fully functional pulp-dentin complex regeneration, namely, cell-based (cell transplantation) and cell homing (through revascularization or homing by injection of stem cells in situ or intravenously) therapies, with each demonstrating advantages as well as drawbacks, especially in clinical application. The present review is aimed at elaborating on these two techniques in the treatment of irreversibly inflamed or necrotic pulp, which is aimed at regenerating a fully functional pulp-dentin complex.
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spelling pubmed-85051252021-10-12 Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration Ahmed, Geraldine M. Abouauf, Eman A. AbuBakr, Nermeen Fouad, Asmaa M. Dörfer, Christof E. Fawzy El-Sayed, Karim M. Stem Cells Int Review Article Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were introduced for a fully functional pulp-dentin complex regeneration, namely, cell-based (cell transplantation) and cell homing (through revascularization or homing by injection of stem cells in situ or intravenously) therapies, with each demonstrating advantages as well as drawbacks, especially in clinical application. The present review is aimed at elaborating on these two techniques in the treatment of irreversibly inflamed or necrotic pulp, which is aimed at regenerating a fully functional pulp-dentin complex. Hindawi 2021-09-29 /pmc/articles/PMC8505125/ /pubmed/34646323 http://dx.doi.org/10.1155/2021/8483668 Text en Copyright © 2021 Geraldine M. Ahmed et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ahmed, Geraldine M.
Abouauf, Eman A.
AbuBakr, Nermeen
Fouad, Asmaa M.
Dörfer, Christof E.
Fawzy El-Sayed, Karim M.
Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration
title Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration
title_full Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration
title_fullStr Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration
title_full_unstemmed Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration
title_short Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration
title_sort cell-based transplantation versus cell homing approaches for pulp-dentin complex regeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505125/
https://www.ncbi.nlm.nih.gov/pubmed/34646323
http://dx.doi.org/10.1155/2021/8483668
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