HIV-1 viral blips are associated with repeated and increasingly high levels of cell-associated HIV-1 RNA transcriptional activity

Some HIV+ patients, virally suppressed on ART, show occasional ‘blips’ of detectable HIV-1 plasma RNA. We used a new highly sensitive assay of cell-associated HIV-1 RNA to measure transcriptional activity in PBMCs and production of infectious virus from the viral reservoir, in patients with and with...

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Detalles Bibliográficos
Autores principales: Suzuki, Kazuo, Levert, Angelique, Yeung, Julie, Starr, Mitchell, Cameron, Jane, Williams, Raffaella, Rismanto, Nikolas, Stark, Tayla, Druery, Dylan, Prasad, Salzeena, Ferrarini, Cristina, Hanafi, Imelda, McNally, Leon Patrick, Cunningham, Philip, Liu, Zhixin, Ishida, Takaomi, Huang, Chin-Shiou, Oswald, Velma, Evans, Louise, Symonds, Geoffrey, Brew, Bruce James, Zaunders, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505147/
https://www.ncbi.nlm.nih.gov/pubmed/34148986
http://dx.doi.org/10.1097/QAD.0000000000003001

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