Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice

Heterozygous mutation of chromodomain helicase DNA binding protein 8 (CHD8) is strongly associated with autism spectrum disorder (ASD) and results in dysregulated expression of neurodevelopmental and synaptic genes during brain development. To reveal how these changes affect ASD-associated cortical...

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Detalles Bibliográficos
Autores principales: Ellingford, Robert A., Panasiuk, Martyna J., de Meritens, Emilie Rabesahala, Shaunak, Raghav, Naybour, Liam, Browne, Lorcan, Basson, M. Albert, Andreae, Laura C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505247/
https://www.ncbi.nlm.nih.gov/pubmed/33837267
http://dx.doi.org/10.1038/s41380-021-01070-9

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