Cargando…

Activity of preclinical and phase I clinical trial of a novel androgen receptor antagonist GT0918 in metastatic breast cancer

PURPOSE: To evaluate GT0918, a 2nd-generation AR antagonist, for its AR down-regulation activity among breast cancer patients. METHODS: The effect of GT0918 on AR protein expression was evaluated in AR expression breast cancer cells and in breast cancer xenograft model. A 3 + 3 phase I dose-escalati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Huiping, Song, Guohong, Zhou, Qiaoxia, Ran, Ran, Jiang, Hanfang, Zhang, Ruyan, Liu, Yaxin, Zhang, Jiayang, Meng, Luping, Ma, Liandong, Sun, Ye, Wang, Meiyu, Zhou, Qingqing, Yan, Honghua, Zhou, Qianxiang, Dong, Xunwei, Tong, Youzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Clinical Trial
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505310/ https://www.ncbi.nlm.nih.gov/pubmed/34392453 http://dx.doi.org/10.1007/s10549-021-06345-x

Ejemplares similares

Pegylated liposomal doxorubicin (Duomeisu(®)) monotherapy in patients with HER2-negative metastatic breast cancer heavily pretreated with anthracycline and taxanes: a single-arm, phase II study
por: Jiang, Hanfang, et al.
Publicado: (2023)

Prognostic Value of Pretreatment Neutrophil-to-Lymphocyte Ratio in HER2-Positive Metastatic Breast Cancer
por: Shao, Bin, et al.
Publicado: (2022)

The prognostic value of neutrophil-to-lymphocyte ratio in de novo stage IV breast cancer: a retrospective cohort study
por: Shao, Bin, et al.
Publicado: (2023)

Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016)
por: Jiang, Hanfang, et al.
Publicado: (2021)

Efficacy and Safety of Fulvestrant 500mg in Hormone-receptor Positive Human Epidermal Receptor 2 Negative Advanced Breast Cancer: A Real-world Study in China
por: Lei, Wen, et al.
Publicado: (2020)

Efficacy and safety of proxalutamide (GT0918) in severe or critically ill patients with COVID-19: study protocol for a prospective, open-label, single-arm, single-center exploratory trial
por: Yang, Dawei, et al.
Publicado: (2023)

Clinicopathological features and prognosis of patients with pregnancy‐associated breast cancer: A matched case control study
por: Zhang, Ruyan, et al.
Publicado: (2021)

P09.18 COVID-19 Outcomes in Patients With Thoracic Malignancies According to Gender and Ethnicity (TERAVOLT)
por: Whisenant, J., et al.
Publicado: (2021)

Efficacy of apatinib 250 mg combined with chemotherapy in patients with pretreated advanced breast cancer in a real-world setting
por: Zhang, Ruyan, et al.
Publicado: (2023)

The prognostic value of chemotherapy or endocrine therapy choice according to circulating tumor cell count in HR(+)HER2(−) metastatic breast cancer: a retrospective study
por: Shao, Bin, et al.
Publicado: (2022)

The efficacy and safety of enzalutamide with trastuzumab in patients with HER2+ and androgen receptor-positive metastatic or locally advanced breast cancer
por: Wardley, Andrew, et al.
Publicado: (2021)

Long term use of bevacizumab in the treatment of triple negative breast cancer with giant tumor in chest wall: A case report
por: Gui, Xinyu, et al.
Publicado: (2018)

Multicenter phase II study of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis
por: Li, Huiping, et al.
Publicado: (2021)

Visceral Fat Obesity Correlates with Frailty in Middle-Aged and Older Adults
por: Li, Bixi, et al.
Publicado: (2022)

Age-dependent development of liver fibrosis in Glmp(gt/gt) mice
por: Nesset, Cecilie K., et al.
Publicado: (2016)

Germline Mutational Landscape in Chinese Patients With Advanced Breast Cancer
por: Zhang, Jiayang, et al.
Publicado: (2022)

Phase II Study of Dehydroepiandrosterone in Androgen Receptor‐Positive Metastatic Breast Cancer
por: Pietri, Elisabetta, et al.
Publicado: (2018)

ARGO Sensitivity to Detect GRBs with E $\gt$ 10GeV
por: Zhou, X X
Publicado: (2005)

0918. Grey matter perfusion is preserved during normotensive hypovolaemia, despite reductions in total cerebral blood flow: evidence of local, pressure independent, intra-cerebral vascular autoregulatory response
por: Beards, SC, et al.
Publicado: (2014)

Search for the Higgs boson in the H ->WW->lvlv channel in ATLAS
por: Armbruster, A
Publicado: (2011)

Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids
por: Martínez-Rivera, Freddyson J., et al.
Publicado: (2017)

H->tau tau and H->tau nu with the ATLAS Detector at the LHC
por: Goncalo, R
Publicado: (2011)

Study of H(SUSY) -> Tautau -> l + Tau Jet + Etmis in CMS
por: Kinnunen, Ritva, et al.
Publicado: (1997)

Solar origin of Major GMSs with (-50nT>Dst>-100nT)
por: Kaur, S
Publicado: (2005)

Net widens for funding of <i>arXiv</i>
Publicado: (2010)

Search for the SM Higgs Boson in H->WW->lnu lnu with ATLAS
por: Schmidt, E
Publicado: (2012)

2073: Fecal bile acids, fecal short-chain fatty acids and the intestinal microbiota in patients with irritable bowel syndrome (IBS) and control volunteers
por: Shin, Andrea, et al.
Publicado: (2018)

Effects of Pre–Cardiopulmonary Bypass Administration of Dexmedetomidine on Cardiac Injuries and the Inflammatory Response in Valve Replacement Surgery With a Sevoflurane Postconditioning Protocol: A Pilot Study
por: Zhou, Hongmei, et al.
Publicado: (2019)

Bicalutamide plus Aromatase Inhibitor in Patients with Estrogen Receptor‐Positive/Androgen Receptor‐Positive Advanced Breast Cancer
por: Lu, Qianyi, et al.
Publicado: (2019)

Spitzenforschung im Kleinformat >
Publicado: (2009)

First Observation of the process Z -> tautau -> emu + 4nu with the ATLAS Detector
por: The ATLAS collaboration
Publicado: (2011)

Search for the Higgs boson in the H->WW->lnln decay mode with the ATLAS Detector
por: The ATLAS collaboration
Publicado: (2011)

Data Driven W+jets background estimation for H->WW->llvv(Higgs)
por: Asfandiyarov, R
Publicado: (2012)

<em>Reg</em> reader unlocks secrets of LHC restart
Publicado: (2009)

Study of pp -> jjH with H -> WW -> lepton+neutrino+2 jets in CMS for M(H) = 300 and 600 GeV
por: Yildiz, Hatice, et al.
Publicado: (2001)

Study for a High Level Trigger for the Decay Channel Bs->Ds pi->Phi pi pi->K K pi pi
por: Giassi, Alessandro, et al.
Publicado: (2002)

Comparison of the safety and efficiency of temporary cardiac pacing methods during left bundle branch pacemaker implantation: Femoral vein pacing versus atrial spiral pacing with electrodes placed at the ventricle
por: Li, Zhenwei, et al.
Publicado: (2023)

Soybean Trihelix Transcription Factors GmGT-2A and GmGT-2B Improve Plant Tolerance to Abiotic Stresses in Transgenic Arabidopsis
por: Xie, Zong-Ming, et al.
Publicado: (2009)

Search for a Heavy SM Higgs Boson in the H -> ZZ -> llqq Channel at ATLAS
por: Gwilliam, C B
Publicado: (2011)

Measurement of the Z->tau tau and W-> tau nu cross sections with the ATLAS detector
por: Griffiths, J
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_m2aqc2h8lkfbhhm374f42mcc4j