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Disease recurrence after colorectal cancer surgery in the modern era: a population-based study

PURPOSE: This population-based study determined the cumulative incidence (CI) of local, regional, and distant recurrences, examined metastatic patterns, and identified risk factors for recurrence after curative treatment for CRC. METHODS: All patients undergoing resection for pathological stage I–II...

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Autores principales: Qaderi, Seyed M., Galjart, Boris, Verhoef, Cornelis, Slooter, Gerrit D., Koopman, Miriam, Verhoeven, Robert H. A., de Wilt, Johannes H. W., van Erning, Felice N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505312/
https://www.ncbi.nlm.nih.gov/pubmed/33813606
http://dx.doi.org/10.1007/s00384-021-03914-w
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author Qaderi, Seyed M.
Galjart, Boris
Verhoef, Cornelis
Slooter, Gerrit D.
Koopman, Miriam
Verhoeven, Robert H. A.
de Wilt, Johannes H. W.
van Erning, Felice N.
author_facet Qaderi, Seyed M.
Galjart, Boris
Verhoef, Cornelis
Slooter, Gerrit D.
Koopman, Miriam
Verhoeven, Robert H. A.
de Wilt, Johannes H. W.
van Erning, Felice N.
author_sort Qaderi, Seyed M.
collection PubMed
description PURPOSE: This population-based study determined the cumulative incidence (CI) of local, regional, and distant recurrences, examined metastatic patterns, and identified risk factors for recurrence after curative treatment for CRC. METHODS: All patients undergoing resection for pathological stage I–III CRC between January 2015 and July 2015 and registered in the Netherlands Cancer Registry were selected (N = 5412). Additional patient record review and data collection on recurrences was conducted by trained administrators in 2019. Three-year CI of recurrence was calculated according to sublocation (right-sided: RCC, left-sided: LCC and rectal cancer: RC) and stage. Cox competing risk regression analyses were used to identify risk factors for recurrence. RESULTS: The 3-year CI of recurrence for stage I, II, and III RCC and LCC was 0.03 vs. 0.03, 0.12 vs. 0.16, and 0.31 vs. 0.24, respectively. The 3-year CI of recurrence for stage I, II, and III RC was 0.08, 0.24, and 0.38. Distant metastases were found in 14, 12, and 16% of patients with RCC, LCC, and RC. Multiple site metastases were found often in patients with RCC, LCC, and RC (42 vs. 32 vs. 28%). Risk factors for recurrence in stage I–II CRC were age 65–74 years, pT4 tumor size, and poor tumor differentiation whereas in stage III CRC, these were ASA III, pT4 tumor size, N2, and poor tumor differentiation. CONCLUSIONS: Recurrence rates in recently treated patients with CRC were lower than reported in the literature and the metastatic pattern and recurrence risks varied between anatomical sublocations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00384-021-03914-w.
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spelling pubmed-85053122021-10-19 Disease recurrence after colorectal cancer surgery in the modern era: a population-based study Qaderi, Seyed M. Galjart, Boris Verhoef, Cornelis Slooter, Gerrit D. Koopman, Miriam Verhoeven, Robert H. A. de Wilt, Johannes H. W. van Erning, Felice N. Int J Colorectal Dis Original Article PURPOSE: This population-based study determined the cumulative incidence (CI) of local, regional, and distant recurrences, examined metastatic patterns, and identified risk factors for recurrence after curative treatment for CRC. METHODS: All patients undergoing resection for pathological stage I–III CRC between January 2015 and July 2015 and registered in the Netherlands Cancer Registry were selected (N = 5412). Additional patient record review and data collection on recurrences was conducted by trained administrators in 2019. Three-year CI of recurrence was calculated according to sublocation (right-sided: RCC, left-sided: LCC and rectal cancer: RC) and stage. Cox competing risk regression analyses were used to identify risk factors for recurrence. RESULTS: The 3-year CI of recurrence for stage I, II, and III RCC and LCC was 0.03 vs. 0.03, 0.12 vs. 0.16, and 0.31 vs. 0.24, respectively. The 3-year CI of recurrence for stage I, II, and III RC was 0.08, 0.24, and 0.38. Distant metastases were found in 14, 12, and 16% of patients with RCC, LCC, and RC. Multiple site metastases were found often in patients with RCC, LCC, and RC (42 vs. 32 vs. 28%). Risk factors for recurrence in stage I–II CRC were age 65–74 years, pT4 tumor size, and poor tumor differentiation whereas in stage III CRC, these were ASA III, pT4 tumor size, N2, and poor tumor differentiation. CONCLUSIONS: Recurrence rates in recently treated patients with CRC were lower than reported in the literature and the metastatic pattern and recurrence risks varied between anatomical sublocations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00384-021-03914-w. Springer Berlin Heidelberg 2021-04-04 2021 /pmc/articles/PMC8505312/ /pubmed/33813606 http://dx.doi.org/10.1007/s00384-021-03914-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Qaderi, Seyed M.
Galjart, Boris
Verhoef, Cornelis
Slooter, Gerrit D.
Koopman, Miriam
Verhoeven, Robert H. A.
de Wilt, Johannes H. W.
van Erning, Felice N.
Disease recurrence after colorectal cancer surgery in the modern era: a population-based study
title Disease recurrence after colorectal cancer surgery in the modern era: a population-based study
title_full Disease recurrence after colorectal cancer surgery in the modern era: a population-based study
title_fullStr Disease recurrence after colorectal cancer surgery in the modern era: a population-based study
title_full_unstemmed Disease recurrence after colorectal cancer surgery in the modern era: a population-based study
title_short Disease recurrence after colorectal cancer surgery in the modern era: a population-based study
title_sort disease recurrence after colorectal cancer surgery in the modern era: a population-based study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505312/
https://www.ncbi.nlm.nih.gov/pubmed/33813606
http://dx.doi.org/10.1007/s00384-021-03914-w
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