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Comparison of analytical techniques to quantitate the capsid content of adeno-associated viral vectors

Adeno-associated virus (AAV) vectors, which contain a DNA transgene packaged into a protein capsid, have shown tremendous therapeutic potential in recent years. An inherent characteristic of the manufacturing process is production of empty capsids that lack the transgene and are therefore unable to...

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Detalles Bibliográficos
Autores principales:	Werle, Amanda K., Powers, Thomas W., Zobel, James F., Wappelhorst, Caitlin N., Jarrold, Martin F., Lyktey, Nicholas A., Sloan, Courtney D.K., Wolf, Andrew J., Adams-Hall, Sharee, Baldus, Phoebe, Runnels, Herbert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505359/ https://www.ncbi.nlm.nih.gov/pubmed/34703846 http://dx.doi.org/10.1016/j.omtm.2021.08.009

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