Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis

Metabolic reprogramming is a core hallmark of cancer and is key for tumorigenesis and tumor progression. Investigation of metabolic perturbation by anti-cancer compounds would allow a thorough understanding of the underlying mechanisms of these agents and identification of new anti-cancer targets. H...

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Detalles Bibliográficos
Autores principales: Liu, Dan, Jin, Xing, Yu, Guanzhen, Wang, Mingsong, Liu, Lei, Zhang, Wenjuan, Wu, Jia, Wang, Fengying, Yang, Jing, Luo, Qin, Cai, Lili, Yang, Xi, Ke, Xisong, Qu, Yi, Xu, Zhenye, Jia, Lijun, Chen, Wen-Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505360/
https://www.ncbi.nlm.nih.gov/pubmed/34703880
http://dx.doi.org/10.1016/j.omto.2021.08.013

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