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The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise

PURPOSE: Variations in substrate metabolism have been identified in women during continuous steady-state aerobic exercise performed at the same relative intensity throughout discrete phases of the menstrual cycle, although some evidence exists that this is abolished when carbohydrate is ingested. Th...

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Autores principales: Hulton, A. T., Malone, J. J., Campbell, I. T., MacLaren, D. P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505395/
https://www.ncbi.nlm.nih.gov/pubmed/34235576
http://dx.doi.org/10.1007/s00421-021-04754-w
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author Hulton, A. T.
Malone, J. J.
Campbell, I. T.
MacLaren, D. P. M.
author_facet Hulton, A. T.
Malone, J. J.
Campbell, I. T.
MacLaren, D. P. M.
author_sort Hulton, A. T.
collection PubMed
description PURPOSE: Variations in substrate metabolism have been identified in women during continuous steady-state aerobic exercise performed at the same relative intensity throughout discrete phases of the menstrual cycle, although some evidence exists that this is abolished when carbohydrate is ingested. This investigation examined the effects of a supraphysiologic exogenous glucose infusion protocol, administered during two phases of the menstrual cycle (follicular and luteal) in eumenorrheic women to identify differences between metabolic, hormonal and substrate oxidative responses. METHODS: During the experimental conditions, blood glucose was infused intravenously at rates to “clamp” blood glucose at 10 mM in seven healthy females (age 20 ± 1 y, mass 55.0 ± 4.1 kg, [Formula: see text] 40.0 ± 1.8 ml/kg/min). Following 30 min of seated rest, participants exercised on a cycle ergometer for 90 min at 60% [Formula: see text] . During the rest period and throughout exercise, blood metabolites and hormones were collected at regular intervals, in addition to expired air for the measurement of substrate oxidation. RESULTS: Significant differences between ovarian hormones and menstrual phase were identified, with estrogen significantly higher during the luteal phase compared to the follicular phase (213.28 ± 30.70 pmol/l vs 103.86 ± 13.85 pmol/l; p = 0.016), and for progesterone (14.23 ± 4.88 vs 2.11 ± 0.36 nmol/l; p = 0.042). However, no further significance was identified in any of the hormonal, metabolite or substrate utilisation patterns between phases. CONCLUSION: These data demonstrate that the infusion of a supraphysiological glucose dose curtails any likely metabolic influence employed by the fluctuation of ovarian hormones in eumenorrheic women during moderate exercise.
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spelling pubmed-85053952021-10-19 The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise Hulton, A. T. Malone, J. J. Campbell, I. T. MacLaren, D. P. M. Eur J Appl Physiol Original Article PURPOSE: Variations in substrate metabolism have been identified in women during continuous steady-state aerobic exercise performed at the same relative intensity throughout discrete phases of the menstrual cycle, although some evidence exists that this is abolished when carbohydrate is ingested. This investigation examined the effects of a supraphysiologic exogenous glucose infusion protocol, administered during two phases of the menstrual cycle (follicular and luteal) in eumenorrheic women to identify differences between metabolic, hormonal and substrate oxidative responses. METHODS: During the experimental conditions, blood glucose was infused intravenously at rates to “clamp” blood glucose at 10 mM in seven healthy females (age 20 ± 1 y, mass 55.0 ± 4.1 kg, [Formula: see text] 40.0 ± 1.8 ml/kg/min). Following 30 min of seated rest, participants exercised on a cycle ergometer for 90 min at 60% [Formula: see text] . During the rest period and throughout exercise, blood metabolites and hormones were collected at regular intervals, in addition to expired air for the measurement of substrate oxidation. RESULTS: Significant differences between ovarian hormones and menstrual phase were identified, with estrogen significantly higher during the luteal phase compared to the follicular phase (213.28 ± 30.70 pmol/l vs 103.86 ± 13.85 pmol/l; p = 0.016), and for progesterone (14.23 ± 4.88 vs 2.11 ± 0.36 nmol/l; p = 0.042). However, no further significance was identified in any of the hormonal, metabolite or substrate utilisation patterns between phases. CONCLUSION: These data demonstrate that the infusion of a supraphysiological glucose dose curtails any likely metabolic influence employed by the fluctuation of ovarian hormones in eumenorrheic women during moderate exercise. Springer Berlin Heidelberg 2021-07-08 2021 /pmc/articles/PMC8505395/ /pubmed/34235576 http://dx.doi.org/10.1007/s00421-021-04754-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Hulton, A. T.
Malone, J. J.
Campbell, I. T.
MacLaren, D. P. M.
The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise
title The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise
title_full The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise
title_fullStr The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise
title_full_unstemmed The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise
title_short The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise
title_sort effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505395/
https://www.ncbi.nlm.nih.gov/pubmed/34235576
http://dx.doi.org/10.1007/s00421-021-04754-w
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