RETRACTED ARTICLE: Phosphor-IWS1-dependent U2AF2 splicing regulates trafficking of CAR-E-positive intronless gene mRNAs and sensitivity to viral infection

AKT-phosphorylated IWS1 promotes Histone H3K36 trimethylation and alternative RNA splicing of target genes, including the U2AF65 splicing factor-encoding U2AF2. The predominant U2AF2 transcript, upon IWS1 phosphorylation block, lacks the RS-domain-encoding exon 2, and encodes a protein which fails t...

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Detalles Bibliográficos
Autores principales: Laliotis, Georgios I., Kenney, Adam D., Chavdoula, Evangelia, Orlacchio, Arturo, Kaba, Abdul, La Ferlita, Alessandro, Anastas, Vollter, Tsatsanis, Christos, Beane, Joal D., Sehgal, Lalit, Coppola, Vincenzo, Yount, Jacob S., Tsichlis, Philip N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505486/
https://www.ncbi.nlm.nih.gov/pubmed/34635782
http://dx.doi.org/10.1038/s42003-021-02668-z

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