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Ascorbate Deficiency Confers Resistance to Hippocampal Neurodegeneration after Asphyxial Cardiac Arrest in Juvenile Rats

BACKGROUND: Asphyxial cardiac arrest (CA) is a significant cause of death and disability in children. Using juvenile Osteogenic disorder Shionogi (ODS) rats that, like humans, do not synthesize ascorbate, we tested the effect of ascorbate deficiency on functional and histological outcome after CA. M...

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Detalles Bibliográficos
Autores principales: Wolf, Michael S., Manole, Mioara D., New, Lee Ann, Chen, Yaming, Soysal, Elif, Kochanek, Patrick M., Bayır, Hülya, Clark, Robert S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505544/
https://www.ncbi.nlm.nih.gov/pubmed/33846553
http://dx.doi.org/10.1038/s41390-021-01515-5