Preclinical evidence to support repurposing everolimus for craving reduction during protracted drug withdrawal

Cue-elicited drug-craving is a cardinal feature of addiction that intensifies (incubates) during protracted withdrawal. In a rat model, these addiction-related behavioral pathologies are mediated, respectively, by time-dependent increases in PI3K/Akt1 signaling and reduced Group 1 metabotropic gluta...

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Detalles Bibliográficos
Autores principales: Chiu, Alvin S., Kang, Matthew C., Huerta Sanchez, Laura L., Fabella, Anne M., Holder, Kalysta N., Barger, Brooke D., Elias, Kristina N., Shin, Christina B., Jimenez Chavez, C. Leonardo, Kippin, Tod E., Szumlinski, Karen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505628/
https://www.ncbi.nlm.nih.gov/pubmed/34188183
http://dx.doi.org/10.1038/s41386-021-01064-9

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