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Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis
With the increasing incidence of ulcerative colitis (UC) in China, Chinese medicinal herbs or relatively active compounds are widely applied in treating UC. These medicines may be combined with other therapeutic agents such as vitamin D(3). Nevertheless, the efficacy of these combinations for UC is...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505666/ https://www.ncbi.nlm.nih.gov/pubmed/34650431 http://dx.doi.org/10.3389/fphar.2021.714065 |
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author | Lu, Yingyu Chen, Jianqiang He, Xueling Xu, Shuoxi Chen, Yong-er Gao, Jie Hou, Shaozhen |
author_facet | Lu, Yingyu Chen, Jianqiang He, Xueling Xu, Shuoxi Chen, Yong-er Gao, Jie Hou, Shaozhen |
author_sort | Lu, Yingyu |
collection | PubMed |
description | With the increasing incidence of ulcerative colitis (UC) in China, Chinese medicinal herbs or relatively active compounds are widely applied in treating UC. These medicines may be combined with other therapeutic agents such as vitamin D(3). Nevertheless, the efficacy of these combinations for UC is unclear. Geniposide is an active component in many Chinese herbal medicines. It could ameliorate dextran sulfate sodium (DSS)–induced colitis in mice. This study was designed to determine the efficacy and mechanism of the single use and combination of geniposide and vitamin D(3) on a mouse model of acute colitis. Data showed that a single administration of geniposide (2 mg/kg) or vitamin D(3) (4 IU/day) could significantly improve the symptoms of UC and relieve colon damage. Geniposide and vitamin D could significantly decrease the levels of TNF-α and IL-6 in serum and colon, and increase the level of IL-10 in the colon. However, the combined treatment of geniposide (2 mg/kg) and vitamin D(3) (4 IU/day) exerted less beneficial effects on UC in mice, indicating by less improvement of UC symptoms, colon damage, and inflammatory infiltration. The combination only downregulated the level of TNF-α in serum and IL-6 in the colon. Our data further demonstrated that geniposide could inhibit the activation of p38 MAPK and then restrict the vitamin D receptor signaling stimulated by vitamin D(3). These results implied that the combination of geniposide and vitamin D(3) might not be an ideal combined treatment for acute colitis, and the combination of vitamin D supplementary and geniposide (or herbal medicines rich in geniposide) need more evaluation before being applied to treat UC in clinic. |
format | Online Article Text |
id | pubmed-8505666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85056662021-10-13 Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis Lu, Yingyu Chen, Jianqiang He, Xueling Xu, Shuoxi Chen, Yong-er Gao, Jie Hou, Shaozhen Front Pharmacol Pharmacology With the increasing incidence of ulcerative colitis (UC) in China, Chinese medicinal herbs or relatively active compounds are widely applied in treating UC. These medicines may be combined with other therapeutic agents such as vitamin D(3). Nevertheless, the efficacy of these combinations for UC is unclear. Geniposide is an active component in many Chinese herbal medicines. It could ameliorate dextran sulfate sodium (DSS)–induced colitis in mice. This study was designed to determine the efficacy and mechanism of the single use and combination of geniposide and vitamin D(3) on a mouse model of acute colitis. Data showed that a single administration of geniposide (2 mg/kg) or vitamin D(3) (4 IU/day) could significantly improve the symptoms of UC and relieve colon damage. Geniposide and vitamin D could significantly decrease the levels of TNF-α and IL-6 in serum and colon, and increase the level of IL-10 in the colon. However, the combined treatment of geniposide (2 mg/kg) and vitamin D(3) (4 IU/day) exerted less beneficial effects on UC in mice, indicating by less improvement of UC symptoms, colon damage, and inflammatory infiltration. The combination only downregulated the level of TNF-α in serum and IL-6 in the colon. Our data further demonstrated that geniposide could inhibit the activation of p38 MAPK and then restrict the vitamin D receptor signaling stimulated by vitamin D(3). These results implied that the combination of geniposide and vitamin D(3) might not be an ideal combined treatment for acute colitis, and the combination of vitamin D supplementary and geniposide (or herbal medicines rich in geniposide) need more evaluation before being applied to treat UC in clinic. Frontiers Media S.A. 2021-09-28 /pmc/articles/PMC8505666/ /pubmed/34650431 http://dx.doi.org/10.3389/fphar.2021.714065 Text en Copyright © 2021 Lu, Chen, He, Xu, Chen, Gao and Hou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Lu, Yingyu Chen, Jianqiang He, Xueling Xu, Shuoxi Chen, Yong-er Gao, Jie Hou, Shaozhen Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis |
title | Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis |
title_full | Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis |
title_fullStr | Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis |
title_full_unstemmed | Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis |
title_short | Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis |
title_sort | combined administration of vitamin d(3) and geniposide is less effective than single use of vitamin d(3) or geniposide in the treatment of ulcerative colitis |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505666/ https://www.ncbi.nlm.nih.gov/pubmed/34650431 http://dx.doi.org/10.3389/fphar.2021.714065 |
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