A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

Expansion of the polyglutamine tract in the N terminus of Ataxin-1 is the main cause of the neurodegenerative disease, spinocerebellar ataxia type 1 (SCA1). However, the C-terminal part of the protein – including its AXH domain and a phosphorylation on residue serine 776 – also plays a crucial role...

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Detalles Bibliográficos
Autores principales: Leysen, Seppe, Burnley, Rebecca Jane, Rodriguez, Elizabeth, Milroy, Lech-Gustav, Soini, Lorenzo, Adamski, Carolyn J., Nitschke, Larissa, Davis, Rachel, Obsil, Tomas, Brunsveld, Lucas, Crabbe, Tom, Zoghbi, Huda Yahya, Ottmann, Christian, Davis, Jeremy Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505757/
https://www.ncbi.nlm.nih.gov/pubmed/34302818
http://dx.doi.org/10.1016/j.jmb.2021.167174

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