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Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages

Post-translational modifications (PTMs) allow proteins to regulate their structure, localisation and function in response to cell intrinsic and environmental signals. The diversity and number of modifications on proteins increase the complexity of cellular proteomes by orders of magnitude. Several p...

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Detalles Bibliográficos
Autores principales: Johnson, Nila, Philip, Nisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505795/
https://www.ncbi.nlm.nih.gov/pubmed/34324911
http://dx.doi.org/10.1016/j.molbiopara.2021.111406
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author Johnson, Nila
Philip, Nisha
author_facet Johnson, Nila
Philip, Nisha
author_sort Johnson, Nila
collection PubMed
description Post-translational modifications (PTMs) allow proteins to regulate their structure, localisation and function in response to cell intrinsic and environmental signals. The diversity and number of modifications on proteins increase the complexity of cellular proteomes by orders of magnitude. Several proteomic and molecular studies have revealed an abundance of PTMs in malaria parasite proteome, where mediators of PTMs play crucial roles in parasite pathogenesis and transmission. In this article, we discuss recent findings in asexual stages of ten diverse PTMs and investigate whether these proteins are expressed in sexual stages. We discovered 25–50 % of proteins exhibiting post-translational modifications in asexual stages are also expressed in sexual stage gametocytes. Moreover we analyse the function of the modified proteins shared with the gametocyte proteome and try to encourage the scientific community to investigate the roles of diverse PTMs beyond phosphorylation in sexual stages which could not only reveal unique aspects of parasite biology, but also uncover new avenues for transmission blocking.
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spelling pubmed-85057952021-10-13 Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages Johnson, Nila Philip, Nisha Mol Biochem Parasitol Article Post-translational modifications (PTMs) allow proteins to regulate their structure, localisation and function in response to cell intrinsic and environmental signals. The diversity and number of modifications on proteins increase the complexity of cellular proteomes by orders of magnitude. Several proteomic and molecular studies have revealed an abundance of PTMs in malaria parasite proteome, where mediators of PTMs play crucial roles in parasite pathogenesis and transmission. In this article, we discuss recent findings in asexual stages of ten diverse PTMs and investigate whether these proteins are expressed in sexual stages. We discovered 25–50 % of proteins exhibiting post-translational modifications in asexual stages are also expressed in sexual stage gametocytes. Moreover we analyse the function of the modified proteins shared with the gametocyte proteome and try to encourage the scientific community to investigate the roles of diverse PTMs beyond phosphorylation in sexual stages which could not only reveal unique aspects of parasite biology, but also uncover new avenues for transmission blocking. Elsevier/North-Holland Biomedical Press 2021-09 /pmc/articles/PMC8505795/ /pubmed/34324911 http://dx.doi.org/10.1016/j.molbiopara.2021.111406 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Johnson, Nila
Philip, Nisha
Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages
title Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages
title_full Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages
title_fullStr Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages
title_full_unstemmed Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages
title_short Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages
title_sort beyond phosphorylation: putative roles of post-translational modifications in plasmodium sexual stages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505795/
https://www.ncbi.nlm.nih.gov/pubmed/34324911
http://dx.doi.org/10.1016/j.molbiopara.2021.111406
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