Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicated. Here we dissect IL11 signaling in fibroblasts an...

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Detalles Bibliográficos
Autores principales: Widjaja, Anissa A., Viswanathan, Sivakumar, Jinrui, Dong, Singh, Brijesh K., Tan, Jessie, Wei Ting, Joyce Goh, Lamb, David, Shekeran, Shamini G., George, Benjamin L., Schafer, Sebastian, Carling, David, Adami, Eleonora, Cook, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505966/
https://www.ncbi.nlm.nih.gov/pubmed/34651016
http://dx.doi.org/10.3389/fmolb.2021.740650

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