Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System

Great progress has been made in the understanding of the pathophysiology of cardiovascular diseases (CVDs), and this has improved the prevention and prognosis of CVDs. However, while sex differences in CVDs have been well documented and studied for decades, their full extent remains unclear. Results...

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Autores principales: Ueda, Kazutaka, Fukuma, Nobuaki, Adachi, Yusuke, Numata, Genri, Tokiwa, Hiroyuki, Toyoda, Masayuki, Otani, Akira, Hashimoto, Masaki, Liu, Pang-Yen, Takimoto, Eiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505986/
https://www.ncbi.nlm.nih.gov/pubmed/34650448
http://dx.doi.org/10.3389/fphys.2021.738218
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author Ueda, Kazutaka
Fukuma, Nobuaki
Adachi, Yusuke
Numata, Genri
Tokiwa, Hiroyuki
Toyoda, Masayuki
Otani, Akira
Hashimoto, Masaki
Liu, Pang-Yen
Takimoto, Eiki
author_facet Ueda, Kazutaka
Fukuma, Nobuaki
Adachi, Yusuke
Numata, Genri
Tokiwa, Hiroyuki
Toyoda, Masayuki
Otani, Akira
Hashimoto, Masaki
Liu, Pang-Yen
Takimoto, Eiki
author_sort Ueda, Kazutaka
collection PubMed
description Great progress has been made in the understanding of the pathophysiology of cardiovascular diseases (CVDs), and this has improved the prevention and prognosis of CVDs. However, while sex differences in CVDs have been well documented and studied for decades, their full extent remains unclear. Results of the latest clinical studies provide strong evidence of sex differences in the efficacy of drug treatment for heart failure, thereby possibly providing new mechanistic insights into sex differences in CVDs. In this review, we discuss the significance of sex differences, as rediscovered by recent studies, in the pathogenesis of CVDs. First, we provide an overview of the results of clinical trials to date regarding sex differences and hormone replacement therapy. Then, we discuss the role of sex differences in the maintenance and disruption of cardiovascular tissue homeostasis.
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spelling pubmed-85059862021-10-13 Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System Ueda, Kazutaka Fukuma, Nobuaki Adachi, Yusuke Numata, Genri Tokiwa, Hiroyuki Toyoda, Masayuki Otani, Akira Hashimoto, Masaki Liu, Pang-Yen Takimoto, Eiki Front Physiol Physiology Great progress has been made in the understanding of the pathophysiology of cardiovascular diseases (CVDs), and this has improved the prevention and prognosis of CVDs. However, while sex differences in CVDs have been well documented and studied for decades, their full extent remains unclear. Results of the latest clinical studies provide strong evidence of sex differences in the efficacy of drug treatment for heart failure, thereby possibly providing new mechanistic insights into sex differences in CVDs. In this review, we discuss the significance of sex differences, as rediscovered by recent studies, in the pathogenesis of CVDs. First, we provide an overview of the results of clinical trials to date regarding sex differences and hormone replacement therapy. Then, we discuss the role of sex differences in the maintenance and disruption of cardiovascular tissue homeostasis. Frontiers Media S.A. 2021-09-28 /pmc/articles/PMC8505986/ /pubmed/34650448 http://dx.doi.org/10.3389/fphys.2021.738218 Text en Copyright © 2021 Ueda, Fukuma, Adachi, Numata, Tokiwa, Toyoda, Otani, Hashimoto, Liu and Takimoto. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ueda, Kazutaka
Fukuma, Nobuaki
Adachi, Yusuke
Numata, Genri
Tokiwa, Hiroyuki
Toyoda, Masayuki
Otani, Akira
Hashimoto, Masaki
Liu, Pang-Yen
Takimoto, Eiki
Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System
title Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System
title_full Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System
title_fullStr Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System
title_full_unstemmed Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System
title_short Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System
title_sort sex differences and regulatory actions of estrogen in cardiovascular system
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505986/
https://www.ncbi.nlm.nih.gov/pubmed/34650448
http://dx.doi.org/10.3389/fphys.2021.738218
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