Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept

Objective: To establish a workflow for mitochondrial DNA (mtDNA) CpG methylation using Nanopore whole-genome sequencing and perform first pilot experiments on affected Parkin biallelic mutation carriers (Parkin-PD) and healthy controls. Background: Mitochondria, including mtDNA, are established key...

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Detalles Bibliográficos
Autores principales: Lüth, Theresa, Wasner, Kobi, Klein, Christine, Schaake, Susen, Tse, Ronnie, Pereira, Sandro L., Laß, Joshua, Sinkkonen, Lasse, Grünewald, Anne, Trinh, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506010/
https://www.ncbi.nlm.nih.gov/pubmed/34650424
http://dx.doi.org/10.3389/fnagi.2021.713084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506010/
https://www.ncbi.nlm.nih.gov/pubmed/34650424
http://dx.doi.org/10.3389/fnagi.2021.713084

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