RNA Sequencing Data for FFPE Tumor Blocks Can Be Used for Robust Estimation of Tumor Mutation Burden in Individual Biosamples

Tumor mutation burden (TMB) is a well-known efficacy predictor for checkpoint inhibitor immunotherapies. Currently, TMB assessment relies on DNA sequencing data. Gene expression profiling by RNA sequencing (RNAseq) is another type of analysis that can inform clinical decision-making and including TM...

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Detalles Bibliográficos
Autores principales: Sorokin, Maxim, Gorelyshev, Alexander, Efimov, Victor, Zotova, Evgenia, Zolotovskaia, Marianna, Rabushko, Elizaveta, Kuzmin, Denis, Seryakov, Alexander, Kamashev, Dmitry, Li, Xinmin, Poddubskaya, Elena, Suntsova, Maria, Buzdin, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506044/
https://www.ncbi.nlm.nih.gov/pubmed/34650919
http://dx.doi.org/10.3389/fonc.2021.732644

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