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Mechanisms of Functional Pleiotropy of p73 in Cancer and Beyond

The transcription factor p73 is a structural and functional homolog of TP53, the most famous and frequently mutated tumor-suppressor gene. The TP73 gene can synthesize an overwhelming number of isoforms via splicing events in 5′ and 3′ ends and alternative promoter usage. Although it originally came...

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Detalles Bibliográficos
Autores principales: Logotheti, Stella, Richter, Christin, Murr, Nico, Spitschak, Alf, Marquardt, Stephan, Pützer, Brigitte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506118/
https://www.ncbi.nlm.nih.gov/pubmed/34650986
http://dx.doi.org/10.3389/fcell.2021.737735