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Experimental animal models of drug-induced sensorineural hearing loss: a narrative review
OBJECTIVE: This narrative review describes experimental animal models of sensorineural hearing loss (SNHL) caused by ototoxic agents. BACKGROUND: SNHL primarily results from damage to the sensory organ within the inner ear or the vestibulocochlear nerve (cranial nerve VIII). The main etiology of SNH...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506545/ https://www.ncbi.nlm.nih.gov/pubmed/34733945 http://dx.doi.org/10.21037/atm-21-2508 |
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author | Lin, Xuexin Luo, Jia Tan, Jingqian Yang, Luoying Wang, Mitian Li, Peng |
author_facet | Lin, Xuexin Luo, Jia Tan, Jingqian Yang, Luoying Wang, Mitian Li, Peng |
author_sort | Lin, Xuexin |
collection | PubMed |
description | OBJECTIVE: This narrative review describes experimental animal models of sensorineural hearing loss (SNHL) caused by ototoxic agents. BACKGROUND: SNHL primarily results from damage to the sensory organ within the inner ear or the vestibulocochlear nerve (cranial nerve VIII). The main etiology of SNHL includes genetic diseases, presbycusis, ototoxic agents, infection, and noise exposure. Animal models with functional and anatomic damage to the sensory organ within the inner ear or the vestibulocochlear nerve mimicking the damage seen in humans are employed to explore the mechanism and potential treatment of SNHL. These animal models of SNHL are commonly established using ototoxic agents. METHODS: A literature search of PubMed, Embase, and Web of Science was performed for research articles on hearing loss and ototoxic agents in animal models of hearing loss. CONCLUSIONS: Common ototoxic medications such as aminoglycoside antibiotics (AABs) and platinum antitumor drugs are extensively used to induce SNHL in experimental animals. The effect of ototoxic agents in vivo is influenced by the chemical mechanisms of the ototoxic agents, the species of animal, routes of administration of the ototoxic agents, and the dosage of ototoxic agents. Animal models of drug-induced SNHL contribute to understanding the hearing mechanism and reveal the function of different parts of the auditory system in humans. |
format | Online Article Text |
id | pubmed-8506545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-85065452021-11-02 Experimental animal models of drug-induced sensorineural hearing loss: a narrative review Lin, Xuexin Luo, Jia Tan, Jingqian Yang, Luoying Wang, Mitian Li, Peng Ann Transl Med Review Article OBJECTIVE: This narrative review describes experimental animal models of sensorineural hearing loss (SNHL) caused by ototoxic agents. BACKGROUND: SNHL primarily results from damage to the sensory organ within the inner ear or the vestibulocochlear nerve (cranial nerve VIII). The main etiology of SNHL includes genetic diseases, presbycusis, ototoxic agents, infection, and noise exposure. Animal models with functional and anatomic damage to the sensory organ within the inner ear or the vestibulocochlear nerve mimicking the damage seen in humans are employed to explore the mechanism and potential treatment of SNHL. These animal models of SNHL are commonly established using ototoxic agents. METHODS: A literature search of PubMed, Embase, and Web of Science was performed for research articles on hearing loss and ototoxic agents in animal models of hearing loss. CONCLUSIONS: Common ototoxic medications such as aminoglycoside antibiotics (AABs) and platinum antitumor drugs are extensively used to induce SNHL in experimental animals. The effect of ototoxic agents in vivo is influenced by the chemical mechanisms of the ototoxic agents, the species of animal, routes of administration of the ototoxic agents, and the dosage of ototoxic agents. Animal models of drug-induced SNHL contribute to understanding the hearing mechanism and reveal the function of different parts of the auditory system in humans. AME Publishing Company 2021-09 /pmc/articles/PMC8506545/ /pubmed/34733945 http://dx.doi.org/10.21037/atm-21-2508 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article Lin, Xuexin Luo, Jia Tan, Jingqian Yang, Luoying Wang, Mitian Li, Peng Experimental animal models of drug-induced sensorineural hearing loss: a narrative review |
title | Experimental animal models of drug-induced sensorineural hearing loss: a narrative review |
title_full | Experimental animal models of drug-induced sensorineural hearing loss: a narrative review |
title_fullStr | Experimental animal models of drug-induced sensorineural hearing loss: a narrative review |
title_full_unstemmed | Experimental animal models of drug-induced sensorineural hearing loss: a narrative review |
title_short | Experimental animal models of drug-induced sensorineural hearing loss: a narrative review |
title_sort | experimental animal models of drug-induced sensorineural hearing loss: a narrative review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506545/ https://www.ncbi.nlm.nih.gov/pubmed/34733945 http://dx.doi.org/10.21037/atm-21-2508 |
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