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Estimating tumor mutational burden across multiple cancer types using whole-exome sequencing

BACKGROUND: Tumor mutational burden (TMB) is emerging as a promising biomarker in immune checkpoint inhibitor (ICI) therapy. Despite whole-exome sequencing (WES) being the gold standard for quantifying TMB, TMB is determined by selected targeted panels in most cases, and WES-derived TMB data are lac...

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Detalles Bibliográficos
Autores principales:	Zhou, Chuang, Chen, Song, Xu, Fei, Wei, Jinwang, Zhou, Xiaoyu, Wu, Zhiqiang, Zhao, Longshuan, Liu, Jun, Guo, Wenbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506705/ https://www.ncbi.nlm.nih.gov/pubmed/34733989 http://dx.doi.org/10.21037/atm-21-4227

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