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Development and evaluation of an early death risk prediction model after acute type A aortic dissection
BACKGROUND: The purpose of the study was to assess the relationship between preoperative laboratory examination, clinical imaging data, and postoperative death of patients with acute type A aortic dissection (ATAAD) and to establish a prediction model of hospital death risk after the operation. METH...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506734/ https://www.ncbi.nlm.nih.gov/pubmed/34733994 http://dx.doi.org/10.21037/atm-21-4063 |
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author | Zhang, Yuhui Chen, Tongyun Chen, Qingliang Min, Hou Nan, Jiang Guo, Zhigang |
author_facet | Zhang, Yuhui Chen, Tongyun Chen, Qingliang Min, Hou Nan, Jiang Guo, Zhigang |
author_sort | Zhang, Yuhui |
collection | PubMed |
description | BACKGROUND: The purpose of the study was to assess the relationship between preoperative laboratory examination, clinical imaging data, and postoperative death of patients with acute type A aortic dissection (ATAAD) and to establish a prediction model of hospital death risk after the operation. METHODS: A total of 224 cases of acute Standford A aortic dissection were treated by total arch replacement using a tetrafurcate graft with stented elephant trunk implantation in Tianjin Chest Hospital. Based on preoperative laboratory examination and clinical imaging data of patients with ATAAD, the independent risk factors of postoperative hospital death were obtained using logistic analysis, and a risk prediction model of postoperative hospital death was developed. RESULTS: Independent risk factors of postoperative death in patients with ATAAD were: body mass index (BMI), preoperative neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), creatinine (Cr), D-dimer, high-sensitive cardiac troponin T (hs-CTnT), apolipoprotein A1, left subclavian artery involvement, and iliac artery involvement. The regression equation of postoperative death risk was: logitP1 = −9.584 + 1.060 × NLR + 1.586 × MPV + 1.009 × Cr + 1.067 × D-dimer + 2.023 × hs-CTnT; the regression equation of postoperative death risk was: logitP2 = −3.296 + 3.242 × left subclavian artery involved + 4.564 × iliac artery involved; the regression equation of postoperative death risk was: logitP3 = −12.864 + 1.149 × BMI + 4.731 × left subclavian artery involved + 4.150 × iliac artery involved + 1.064 × NLR + 1.011 × Cr + 1.084 × D-dimer + 2.242 × hs-CTnT + 3.233 × apolipoprotein A1. CONCLUSIONS: BMI, NLR, MPV, Cr, D-dimer, hs-CTnT, apolipoprotein A1, left subclavian artery involvement and iliac artery involvement can affect the hospital mortality rate of aortic dissection undergoing Sun’s operation to varying degrees, which may be helpful to guide the design of the perioperative treatment strategy. |
format | Online Article Text |
id | pubmed-8506734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-85067342021-11-02 Development and evaluation of an early death risk prediction model after acute type A aortic dissection Zhang, Yuhui Chen, Tongyun Chen, Qingliang Min, Hou Nan, Jiang Guo, Zhigang Ann Transl Med Original Article BACKGROUND: The purpose of the study was to assess the relationship between preoperative laboratory examination, clinical imaging data, and postoperative death of patients with acute type A aortic dissection (ATAAD) and to establish a prediction model of hospital death risk after the operation. METHODS: A total of 224 cases of acute Standford A aortic dissection were treated by total arch replacement using a tetrafurcate graft with stented elephant trunk implantation in Tianjin Chest Hospital. Based on preoperative laboratory examination and clinical imaging data of patients with ATAAD, the independent risk factors of postoperative hospital death were obtained using logistic analysis, and a risk prediction model of postoperative hospital death was developed. RESULTS: Independent risk factors of postoperative death in patients with ATAAD were: body mass index (BMI), preoperative neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), creatinine (Cr), D-dimer, high-sensitive cardiac troponin T (hs-CTnT), apolipoprotein A1, left subclavian artery involvement, and iliac artery involvement. The regression equation of postoperative death risk was: logitP1 = −9.584 + 1.060 × NLR + 1.586 × MPV + 1.009 × Cr + 1.067 × D-dimer + 2.023 × hs-CTnT; the regression equation of postoperative death risk was: logitP2 = −3.296 + 3.242 × left subclavian artery involved + 4.564 × iliac artery involved; the regression equation of postoperative death risk was: logitP3 = −12.864 + 1.149 × BMI + 4.731 × left subclavian artery involved + 4.150 × iliac artery involved + 1.064 × NLR + 1.011 × Cr + 1.084 × D-dimer + 2.242 × hs-CTnT + 3.233 × apolipoprotein A1. CONCLUSIONS: BMI, NLR, MPV, Cr, D-dimer, hs-CTnT, apolipoprotein A1, left subclavian artery involvement and iliac artery involvement can affect the hospital mortality rate of aortic dissection undergoing Sun’s operation to varying degrees, which may be helpful to guide the design of the perioperative treatment strategy. AME Publishing Company 2021-09 /pmc/articles/PMC8506734/ /pubmed/34733994 http://dx.doi.org/10.21037/atm-21-4063 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Zhang, Yuhui Chen, Tongyun Chen, Qingliang Min, Hou Nan, Jiang Guo, Zhigang Development and evaluation of an early death risk prediction model after acute type A aortic dissection |
title | Development and evaluation of an early death risk prediction model after acute type A aortic dissection |
title_full | Development and evaluation of an early death risk prediction model after acute type A aortic dissection |
title_fullStr | Development and evaluation of an early death risk prediction model after acute type A aortic dissection |
title_full_unstemmed | Development and evaluation of an early death risk prediction model after acute type A aortic dissection |
title_short | Development and evaluation of an early death risk prediction model after acute type A aortic dissection |
title_sort | development and evaluation of an early death risk prediction model after acute type a aortic dissection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506734/ https://www.ncbi.nlm.nih.gov/pubmed/34733994 http://dx.doi.org/10.21037/atm-21-4063 |
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