Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SAMHD1 inhibitors are promising candidates for the sensitisati...

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Detalles Bibliográficos
Autores principales: Rothenburger, Tamara, Thomas, Dominique, Schreiber, Yannick, Wratil, Paul R., Pflantz, Tamara, Knecht, Kirsten, Digianantonio, Katie, Temple, Joshua, Schneider, Constanze, Baldauf, Hanna-Mari, McLaughlin, Katie-May, Rothweiler, Florian, Bilen, Berna, Farmand, Samira, Bojkova, Denisa, Costa, Rui, Ferreirós, Nerea, Geisslinger, Gerd, Oellerich, Thomas, Xiong, Yong, Keppler, Oliver T., Wass, Mark N., Michaelis, Martin, Cinatl, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507139/
https://www.ncbi.nlm.nih.gov/pubmed/34641952
http://dx.doi.org/10.1186/s13046-021-02093-4

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