FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX

Apoptosis is a programmed cell death that efficiently removes damaged cells to maintain tissue homeostasis. Defect in apoptotic machinery can lead to tumor development, progression, and resistance to chemotherapy. PUMA (p53 upregulated modulator of apoptosis) and BAX (BCL2-associated X protein) are...

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Detalles Bibliográficos
Autores principales: Manne, Rajesh Kumar, Agrawal, Yashika, Malonia, Sunil K., Banday, Shahid, Edachery, Sarathkumar, Patel, Asha, Kumar, Avinash, Shetty, Praveenkumar, Santra, Manas Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507197/
https://www.ncbi.nlm.nih.gov/pubmed/34587475
http://dx.doi.org/10.1016/j.jbc.2021.101253

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