Cargando…

miR-21 regulates ischemic neuronal injury via the p53/Bcl-2/Bax signaling pathway

Focal cerebral ischemia leads to a large number of neuronal apoptosis, and secondary neuronal death is the main cause of cerebral infarction. MicroRNA-21 (miR-21) has been shown to be a strong anti-apoptosis and pro-survival factor in ischemia. However, the precise mechanism of miR-21 in ischemic ne...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Honglin, Huang, Wenxian, Rao, Jie, Yuan, Jingping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507259/ https://www.ncbi.nlm.nih.gov/pubmed/34552038 http://dx.doi.org/10.18632/aging.203530

Ejemplares similares

Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway
por: Yan, Honglin, et al.
Publicado: (2017)

miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway
por: Xiao, Peng, et al.
Publicado: (2020)

Reduced expression of BAX is associated with poor prognosis in patients with epithelial ovarian cancer: a multifactorial analysis of TP53, p21, BAX and BCL-2
por: Schuyer, M, et al.
Publicado: (2001)

Association of miR-21, miR-126 and miR-605 gene polymorphisms with ischemic stroke risk
por: Xiang, Yang, et al.
Publicado: (2017)

miR-145 suppresses the proliferation, invasion and migration of NSCLC cells by regulating the BAX/BCL-2 ratio and the caspase-3 cascade
por: Pan, Yi, et al.
Publicado: (2018)

Early and late apoptosis protein expression (Bcl-2, BAX and p53) in traumatic brachial plexus injury
por: Suroto, Heri, et al.
Publicado: (2021)

Prostate tumours from an Asian population: examination of bax, bcl-2, p53 and ras and identification of bax as prognostic marker
por: Chia, S-J, et al.
Publicado: (2000)

The protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax
por: Shen, Sheng, et al.
Publicado: (2017)

Trimetazidine protects against cardiac ischemia/reperfusion injury via effects on cardiac miRNA-21 expression, Akt and the Bcl-2/Bax pathway
por: Ma, Ning, et al.
Publicado: (2016)

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?
por: Kulsoom, Bibi, et al.
Publicado: (2018)

Total Flavonoids from Carya cathayensis Sarg. Leaves Alleviate H9c2 Cells Hypoxia/Reoxygenation Injury via Effects on miR-21 Expression, PTEN/Akt, and the Bcl-2/Bax Pathway
por: Jiang, Ruibin, et al.
Publicado: (2018)

Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts
por: Escobar, Enrico, et al.
Publicado: (2023)

MiR-21, miR-34a, miR-125b, miR-181d and miR-648 levels inversely correlate with MGMT and TP53 expression in primary glioblastoma patients
por: Jesionek-Kupnicka, Dorota, et al.
Publicado: (2017)

Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis
por: Miao, Guiqiang, et al.
Publicado: (2019)

c[RGDyk]-coated liposomes loaded with adriamycin and miR-21 mimics inhibit the growth of hepatoma cell line SMCC-7721 via up-regulating Bax and p53
por: Wei, Xiaoyong, et al.
Publicado: (2019)

Protective Effects of PPARγ on Renal Ischemia-Reperfusion Injury by Regulating miR-21
por: Huang, Ruizhen, et al.
Publicado: (2022)

miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways
por: Feng, Xue, et al.
Publicado: (2019)

miR-346 Inhibited Apoptosis Against Myocardial Ischemia-Reperfusion Injury via Targeting Bax in Rats
por: Lv, Xiangwei, et al.
Publicado: (2020)

The Action of Bax and Bcl-2 on T Cell Selection
por: Williams, Owen, et al.
Publicado: (1998)

Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21
por: Xu, Xialian, et al.
Publicado: (2012)

Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status
por: Mirjolet, J-F, et al.
Publicado: (2000)

miR-130a alleviates neuronal apoptosis and changes in expression of Bcl-2/Bax and caspase-3 in cerebral infarction rats through PTEN/PI3K/Akt signaling pathway
por: Wang, Yinming, et al.
Publicado: (2020)

LINC00657/miR-26a-5p/CKS2 ceRNA network promotes the growth of esophageal cancer cells via the MDM2/p53/Bcl2/Bax pathway
por: Zhang, Xiao-Mei, et al.
Publicado: (2020)

Comparable expression of miR-let-7b, miR-21, miR-182, miR-145, and p53 in serum and cervical cells: Diagnostic implications for early detection of cervical lesions
por: Okoye, Jude Ogechukwu, et al.
Publicado: (2019)

Expression and predictive value of miR-489 and miR-21 in melanoma metastasis
por: Mo, Hao, et al.
Publicado: (2019)

Effects of Renal Ischemic Postconditioning on Myocardial Ultrastructural Organization and Myocardial Expression of Bcl-2/Bax in Rabbits
por: Zhang, Wen-zhong, et al.
Publicado: (2016)

Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer
por: Larki, Pegah, et al.
Publicado: (2018)

Effects of genistein on neuronal apoptosis, and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats★
por: Peng, Yun, et al.
Publicado: (2012)

Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax
por: Tenório, Jefferson-da Rocha, et al.
Publicado: (2018)

ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway
por: Cao, Yongmei, et al.
Publicado: (2021)

Role of miR-21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning
por: Xu, Xialian, et al.
Publicado: (2017)

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax
por: Billen, Lieven P, et al.
Publicado: (2008)

MiR-486 regulates cardiomyocyte apoptosis by p53-mediated BCL-2 associated mitochondrial apoptotic pathway
por: Sun, Yuhan, et al.
Publicado: (2017)

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours
por: Bornachea, Olga, et al.
Publicado: (2012)

Protective effect of gastrodin on myocardial ischemia-reperfusion injury and the expression of Bax and Bcl-2
por: Han, Xiao, et al.
Publicado: (2019)

MiR-21-5p protects against ischemic stroke by targeting IL-6R
por: Zhan, Lan, et al.
Publicado: (2023)

miR-21 in Human Cardiomyopathies
por: Surina,, et al.
Publicado: (2021)

miR-573 regulates cell proliferation and apoptosis by targeting Bax in nucleus pulposus cells
por: Wang, Rui, et al.
Publicado: (2019)

Reduction of miR-29a-3p induced cardiac ischemia reperfusion injury in mice via targeting Bax
por: Zhang, Liang, et al.
Publicado: (2019)

Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer
por: Schee, Kristina, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_c71v7h5megvs504grg6fslc6dh