A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin

N-retinylidene-N-retinylethanolamine (A2E) plays a central role in age-related macular degeneration (AMD) by inducing angiogenesis and inflammation. A2E effects are mediated at least partly via the retinoic acid receptor (RAR)-α. Here we show that A2E binds and transactivates also peroxisome prolife...

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Detalles Bibliográficos
Autores principales: Fontaine, Valérie, Fournié, Mylène, Monteiro, Elodie, Boumedine, Thinhinane, Balducci, Christine, Guibout, Louis, Latil, Mathilde, Sahel, José-Alain, Veillet, Stanislas, Dilda, Pierre J., Lafont, René, Camelo, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507260/
https://www.ncbi.nlm.nih.gov/pubmed/34544906
http://dx.doi.org/10.18632/aging.203558

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