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High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies

The association between insulin resistance and thyroid carcinoma is controversial. We conducted this meta-analysis of association between insulin resistance and thyroid carcinoma. There were 14 studies included in this meta-analysis. Random-effect model was used to merge the weighted mean difference...

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Autores principales: Zhao, Junyu, Zhang, Qianping, Yang, Yupeng, Yao, Jinming, Liao, Lin, Dong, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507263/
https://www.ncbi.nlm.nih.gov/pubmed/34550096
http://dx.doi.org/10.18632/aging.203529
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author Zhao, Junyu
Zhang, Qianping
Yang, Yupeng
Yao, Jinming
Liao, Lin
Dong, Jianjun
author_facet Zhao, Junyu
Zhang, Qianping
Yang, Yupeng
Yao, Jinming
Liao, Lin
Dong, Jianjun
author_sort Zhao, Junyu
collection PubMed
description The association between insulin resistance and thyroid carcinoma is controversial. We conducted this meta-analysis of association between insulin resistance and thyroid carcinoma. There were 14 studies included in this meta-analysis. Random-effect model was used to merge the weighted mean difference value of fasting serum insulin level and the pooled effect shows that the level of fasting serum insulin is higher in patients with thyroid carcinoma than those of controls (1.88, 95% CI 0.87 to 2.90, P=0.0003). Random-effect model was used to estimate the pooled weighted mean difference and it shows that thyroid carcinoma patients have a higher level of homeostasis model assessment of insulin resistance (HOMA-IR) than patients without thyroid carcinoma (0.54, 95% CI 0.29 to 0.78, P<0.0001). Fixed-effect model with the odds ratio of insulin resistance shows that insulin resistance could increase the risk of thyroid carcinoma 216% compared with participants without insulin resistance (3.16, 95% CI 2.09 to 4.77, P<0.0001). In conclusion, insulin resistance might be a risk factor for thyroid carcinoma.
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spelling pubmed-85072632021-10-14 High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies Zhao, Junyu Zhang, Qianping Yang, Yupeng Yao, Jinming Liao, Lin Dong, Jianjun Aging (Albany NY) Research Paper The association between insulin resistance and thyroid carcinoma is controversial. We conducted this meta-analysis of association between insulin resistance and thyroid carcinoma. There were 14 studies included in this meta-analysis. Random-effect model was used to merge the weighted mean difference value of fasting serum insulin level and the pooled effect shows that the level of fasting serum insulin is higher in patients with thyroid carcinoma than those of controls (1.88, 95% CI 0.87 to 2.90, P=0.0003). Random-effect model was used to estimate the pooled weighted mean difference and it shows that thyroid carcinoma patients have a higher level of homeostasis model assessment of insulin resistance (HOMA-IR) than patients without thyroid carcinoma (0.54, 95% CI 0.29 to 0.78, P<0.0001). Fixed-effect model with the odds ratio of insulin resistance shows that insulin resistance could increase the risk of thyroid carcinoma 216% compared with participants without insulin resistance (3.16, 95% CI 2.09 to 4.77, P<0.0001). In conclusion, insulin resistance might be a risk factor for thyroid carcinoma. Impact Journals 2021-09-22 /pmc/articles/PMC8507263/ /pubmed/34550096 http://dx.doi.org/10.18632/aging.203529 Text en Copyright: © 2021 Zhao et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhao, Junyu
Zhang, Qianping
Yang, Yupeng
Yao, Jinming
Liao, Lin
Dong, Jianjun
High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies
title High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies
title_full High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies
title_fullStr High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies
title_full_unstemmed High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies
title_short High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies
title_sort high prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507263/
https://www.ncbi.nlm.nih.gov/pubmed/34550096
http://dx.doi.org/10.18632/aging.203529
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