Cargando…

Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8(+) T cell infiltration

BACKGROUND: Targeting tumor microenvironment (TME) may provide therapeutic activity and selectivity in treating cancers. Therefore, an improved understanding of the mechanism by which drug targeting TME would enable more informed and effective treatment measures. Glycyrrhiza uralensis Fisch (GUF, li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Jinglin, Huang, Ruifei, Yang, Ruijie, Xiao, Yue, Yan, Jiangna, Zheng, Chunli, Xiao, Wei, Huang, Chao, Wang, Yonghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507331/ https://www.ncbi.nlm.nih.gov/pubmed/34641869 http://dx.doi.org/10.1186/s12935-021-02223-0

Ejemplares similares

Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8(+) T Cells in Local Tumor Microenvironment
por: Yang, Ruijie, et al.
Publicado: (2022)

Relationship between PD-L1 expression, CD8+ T-cell infiltration and prognosis in intrahepatic cholangiocarcinoma patients
por: Deng, Min, et al.
Publicado: (2021)

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)
por: Feng, Daorong, et al.
Publicado: (2015)

Tumor-infiltrating CD4(+) T cells in patients with gastric cancer
por: Yuan, Long, et al.
Publicado: (2017)

MicroRNA-770 affects proliferation and cell cycle transition by directly targeting CDK8 in glioma
por: Zhang, Jun-feng, et al.
Publicado: (2018)

Systems pharmacology dissection of Epimedium targeting tumor microenvironment to enhance cytotoxic T lymphocyte responses in lung cancer
por: Huang, Chao, et al.
Publicado: (2021)

Molecular mechanism of G(1) arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells
por: Tao, Yan-Fang, et al.
Publicado: (2017)

MiRNA-497 regulates cell growth and invasion by targeting cyclin E1 in breast cancer
por: Luo, Qifeng, et al.
Publicado: (2013)

Abnormal expression of CDK11(p58) in prostate cancer
por: Chi, Yayun, et al.
Publicado: (2014)

DFNA5 regulates immune cells infiltration and exhaustion
por: Hu, Jian, et al.
Publicado: (2022)

The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation
por: Wang, Rui-Qi, et al.
Publicado: (2019)

Cyclin D3 predicts disease-free survival in breast cancer
por: Chi, Yayun, et al.
Publicado: (2015)

CD44, a marker of cancer stem cells, is positively correlated with PD-L1 expression and immune cells infiltration in lung adenocarcinoma
por: Zhang, Chenyue, et al.
Publicado: (2020)

CD137 agonist induces gastric cancer cell apoptosis by enhancing the functions of CD8(+) T cells via NF-κB signaling
por: Hu, Ben-Shun, et al.
Publicado: (2020)

Upregulation of ARNTL2 is associated with poor survival and immune infiltration in clear cell renal cell carcinoma
por: Wang, Song, et al.
Publicado: (2021)

Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes
por: Tan, Linda C, et al.
Publicado: (2000)

Correlation of CCL8 expression with immune cell infiltration of skin cutaneous melanoma: potential as a prognostic indicator and therapeutic pathway
por: Yang, Peipei, et al.
Publicado: (2021)

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2
por: Zhang, Wengang, et al.
Publicado: (2023)

Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma
por: Meng, Fei, et al.
Publicado: (2021)

Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44(high)/cd24(low )population which is invasive and resistant to anoikis
por: Gauger, Kelly J, et al.
Publicado: (2009)

CD28-, CD45RA(null/dim) and natural killer-like CD8+ T cells are increased in peripheral blood of women with low-grade cervical lesions
por: Pita-Lopez, Maria Luisa, et al.
Publicado: (2014)

MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6
por: Shao, Yuan, et al.
Publicado: (2013)

Cyclin K goes with Cdk12 and Cdk13
por: Kohoutek, Jiri, et al.
Publicado: (2012)

Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage
por: Xiao, Haowen, et al.
Publicado: (2019)

Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
por: Rekha, Umapathy Vidhya, et al.
Publicado: (2020)

CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro
por: He, Xiangming, et al.
Publicado: (2014)

SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer
por: Dai, Wumin, et al.
Publicado: (2021)

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
por: Zhang, Jiawei, et al.
Publicado: (2022)

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila
por: Xie, Xiao-Jun, et al.
Publicado: (2015)

Serum-derived exosomes promote CD8+ T cells to overexpress PD-1, affecting the prognosis of hypopharyngeal carcinoma
por: Gao, Qian, et al.
Publicado: (2021)

Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma
por: Matsumoto, M, et al.
Publicado: (1999)

β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB
por: Liu, Shu-Guang, et al.
Publicado: (2020)

Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
por: Clemm von Hohenberg, Katharina, et al.
Publicado: (2022)

Down regulation of G protein-coupled receptor 137 expression inhibits proliferation and promotes apoptosis in leukemia cells
por: Men, Li-Jie, et al.
Publicado: (2018)

Cyclin-dependent kinase 9 expression and its association with CD8(+) T cell infiltration in microsatellite-stable colorectal cancer
por: Wang, Jiefu, et al.
Publicado: (2019)

Dendritic cells matured with recombinant human sperm associated antigen 9 (rhSPAG9) induce CD4(+), CD8(+) T cells and activate NK cells: a potential candidate molecule for immunotherapy in cervical cancer
por: Dhandapani, Hemavathi, et al.
Publicado: (2021)

Ultraviolet-A radiation induces changes in cyclin G gene expression in mouse melanoma B16-F1 cells
por: Pastila, Riikka, et al.
Publicado: (2007)

Upregulation of NPL4 promotes bladder cancer cell proliferation by inhibiting DXO destabilization of cyclin D1 mRNA
por: Lu, Bao-Sai, et al.
Publicado: (2019)

Rising Cyclin-CDK Levels Order Cell Cycle Events
por: Oikonomou, Catherine, et al.
Publicado: (2011)

Cyclin H predicts the poor prognosis and promotes the proliferation of ovarian cancer
por: Peng, Chen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1smdj0sn46koqtcs280oqfdjg4