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Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma

BACKGROUND: Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer (NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune checkpoint inhibitors (ICIs) for the treatment of LUAD has been on the rise in the past decade. This study explored the prognostic r...

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Autores principales: Ma, Weishuang, Liang, Jiaming, Mo, Junjian, Zhang, Siyuan, Hu, Ningdong, Tian, Dongbo, Chen, Zisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507344/
https://www.ncbi.nlm.nih.gov/pubmed/34635082
http://dx.doi.org/10.1186/s12885-021-08790-9
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author Ma, Weishuang
Liang, Jiaming
Mo, Junjian
Zhang, Siyuan
Hu, Ningdong
Tian, Dongbo
Chen, Zisheng
author_facet Ma, Weishuang
Liang, Jiaming
Mo, Junjian
Zhang, Siyuan
Hu, Ningdong
Tian, Dongbo
Chen, Zisheng
author_sort Ma, Weishuang
collection PubMed
description BACKGROUND: Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer (NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune checkpoint inhibitors (ICIs) for the treatment of LUAD has been on the rise in the past decade. This study explored the prognostic role of butyrophilin-like 9 (BTNL9) in LUAD. METHODS: Gene expression profile of buytrophilins (BTNs) was determined using the GEPIA database. The effect of BTNL9 on the survival of LUAD patients was assessed using Kaplan-Meier plotter and OncoLnc. Correlation between BTNL9 expression and tumor-infiltrating immune cells (TILs) was explored using TIMER and GEPIA databases. Further, the relationship between BTNL9 expression and drug response was evaluated using CARE. Besides, construction and evaluation of nomogram based on BTNL9 expression and TNM stage. RESULTS: BTNL9 expression was downregulated in LUAD and was associated with a poor probability of 1, 3, 5-years overall survival (OS). In addition, BTNL9 expression was regulated at epigenetic and post-transcriptional modification levels. Moreover, BTNL9 expression was significantly positively correlated with ImmuneScore and ESTIMATEScore. Furthermore, BTNL9 expression was positively associated with infiltration levels of B cells, CD4(+) T cells, and macrophages. Kaplan-Meier analysis showed that BTNL9 expression in B cells and dendritic cells (DCs) was significantly associated with OS. BTNL9 expression was significantly positively correlated with CARE scores. CONCLUSIONS: These findings show that BTNL9 is a potential prognostic biomarker for LUAD. Low BTNL9 expression levels associated with low infiltration levels of naïve B cells, and DCs in the tumor microenvironment are unfavorable for OS in LUAD patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08790-9.
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spelling pubmed-85073442021-10-20 Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma Ma, Weishuang Liang, Jiaming Mo, Junjian Zhang, Siyuan Hu, Ningdong Tian, Dongbo Chen, Zisheng BMC Cancer Research Article BACKGROUND: Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer (NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune checkpoint inhibitors (ICIs) for the treatment of LUAD has been on the rise in the past decade. This study explored the prognostic role of butyrophilin-like 9 (BTNL9) in LUAD. METHODS: Gene expression profile of buytrophilins (BTNs) was determined using the GEPIA database. The effect of BTNL9 on the survival of LUAD patients was assessed using Kaplan-Meier plotter and OncoLnc. Correlation between BTNL9 expression and tumor-infiltrating immune cells (TILs) was explored using TIMER and GEPIA databases. Further, the relationship between BTNL9 expression and drug response was evaluated using CARE. Besides, construction and evaluation of nomogram based on BTNL9 expression and TNM stage. RESULTS: BTNL9 expression was downregulated in LUAD and was associated with a poor probability of 1, 3, 5-years overall survival (OS). In addition, BTNL9 expression was regulated at epigenetic and post-transcriptional modification levels. Moreover, BTNL9 expression was significantly positively correlated with ImmuneScore and ESTIMATEScore. Furthermore, BTNL9 expression was positively associated with infiltration levels of B cells, CD4(+) T cells, and macrophages. Kaplan-Meier analysis showed that BTNL9 expression in B cells and dendritic cells (DCs) was significantly associated with OS. BTNL9 expression was significantly positively correlated with CARE scores. CONCLUSIONS: These findings show that BTNL9 is a potential prognostic biomarker for LUAD. Low BTNL9 expression levels associated with low infiltration levels of naïve B cells, and DCs in the tumor microenvironment are unfavorable for OS in LUAD patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08790-9. BioMed Central 2021-10-11 /pmc/articles/PMC8507344/ /pubmed/34635082 http://dx.doi.org/10.1186/s12885-021-08790-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Ma, Weishuang
Liang, Jiaming
Mo, Junjian
Zhang, Siyuan
Hu, Ningdong
Tian, Dongbo
Chen, Zisheng
Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma
title Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma
title_full Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma
title_fullStr Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma
title_full_unstemmed Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma
title_short Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma
title_sort butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507344/
https://www.ncbi.nlm.nih.gov/pubmed/34635082
http://dx.doi.org/10.1186/s12885-021-08790-9
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