A short review on lymphatic endothelial cell heterogeneity

Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies have also revealed a conserved pattern of gen...

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Autor principal: Miyasaka, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507377/
https://www.ncbi.nlm.nih.gov/pubmed/34635187
http://dx.doi.org/10.1186/s41232-021-00183-6
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author Miyasaka, Masayuki
author_facet Miyasaka, Masayuki
author_sort Miyasaka, Masayuki
collection PubMed
description Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies have also revealed a conserved pattern of gene expression in LECs across animal species, as well as specialized sets of genes unique to each species. However, the extent to which this heterogeneity is adaptive to the external milieu surrounding LECs has remained unclear. The transcriptional and regulatory pathways that program the different subsets of LECs also remain unexplored.
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spelling pubmed-85073772021-10-20 A short review on lymphatic endothelial cell heterogeneity Miyasaka, Masayuki Inflamm Regen Review Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies have also revealed a conserved pattern of gene expression in LECs across animal species, as well as specialized sets of genes unique to each species. However, the extent to which this heterogeneity is adaptive to the external milieu surrounding LECs has remained unclear. The transcriptional and regulatory pathways that program the different subsets of LECs also remain unexplored. BioMed Central 2021-10-11 /pmc/articles/PMC8507377/ /pubmed/34635187 http://dx.doi.org/10.1186/s41232-021-00183-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Miyasaka, Masayuki
A short review on lymphatic endothelial cell heterogeneity
title A short review on lymphatic endothelial cell heterogeneity
title_full A short review on lymphatic endothelial cell heterogeneity
title_fullStr A short review on lymphatic endothelial cell heterogeneity
title_full_unstemmed A short review on lymphatic endothelial cell heterogeneity
title_short A short review on lymphatic endothelial cell heterogeneity
title_sort short review on lymphatic endothelial cell heterogeneity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507377/
https://www.ncbi.nlm.nih.gov/pubmed/34635187
http://dx.doi.org/10.1186/s41232-021-00183-6
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