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Association between previous rheumatoid arthritis and COVID-19 and its severity: a nationwide cohort study in South Korea

OBJECTIVES: The prevalence of rheumatoid arthritis (RA) among patients with COVID-19 and the association between RA and the outcome of COVID-19 remain unclear. We aimed to compare the prevalence of RA between participants with and without COVID-19; we then analysed the association between the presen...

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Autores principales: Jung, Younghee, Kwon, Mihye, Choi, Hyo Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507409/
https://www.ncbi.nlm.nih.gov/pubmed/34620675
http://dx.doi.org/10.1136/bmjopen-2021-054753
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author Jung, Younghee
Kwon, Mihye
Choi, Hyo Geun
author_facet Jung, Younghee
Kwon, Mihye
Choi, Hyo Geun
author_sort Jung, Younghee
collection PubMed
description OBJECTIVES: The prevalence of rheumatoid arthritis (RA) among patients with COVID-19 and the association between RA and the outcome of COVID-19 remain unclear. We aimed to compare the prevalence of RA between participants with and without COVID-19; we then analysed the association between the presence of RA and the severity of COVID-19. DESIGN: A cross-sectional study. SETTING: Data from a nationwide COVID-19 cohort database by the Korea National Health Insurance Corporation were used. PARTICIPANTS AND INTERVENTIONS: A total of 8070 patients with COVID-19 (1 January 2020 through 4 June 2020) were matched with 32 280 control participants with regard to age, sex and income. Patients with COVID-19 were confirmed by SARS-CoV-2 PCR and controls were collected from the database. RA was confirmed using the diagnostic code (International Classification of Disease, Tenth Revision) and medication claim codes. Conditional/unconditional logistic regression was applied to analyse the association between RA and COVID-19. PRIMARY OUTCOME AND SECONDARY OUTCOME: Laboratory confirmation of SARS-CoV-2 infection was defined as the primary outcome. The secondary outcome was severe COVID-19 defined as a history of intensive care unit admission, invasive ventilation or death. RESULTS: The prevalence of RA in the COVID-19 (0.4%, 35/8070) and control (0.4%, 121/32,280) groups did not differ (p=0.446). After adjusting for underlying diseases, no association between RA and COVID-19 was observed (adjusted OR=1.14, 95% CI: 0.78 to 1.67) and COVID-19 severity was not associated with RA (adjusted OR=0.62, 95% CI: 0.14 to 7.29). The overall mortality rate was 2.9% (237/8070) and RA was not significantly associated with mortality (adjusted OR=1.64, 95% CI: 0.33 to 8.15). CONCLUSION: We did not find an association between the presence of RA and COVID-19. In addition, RA was not associated with the severity of COVID-19.
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spelling pubmed-85074092021-10-12 Association between previous rheumatoid arthritis and COVID-19 and its severity: a nationwide cohort study in South Korea Jung, Younghee Kwon, Mihye Choi, Hyo Geun BMJ Open Infectious Diseases OBJECTIVES: The prevalence of rheumatoid arthritis (RA) among patients with COVID-19 and the association between RA and the outcome of COVID-19 remain unclear. We aimed to compare the prevalence of RA between participants with and without COVID-19; we then analysed the association between the presence of RA and the severity of COVID-19. DESIGN: A cross-sectional study. SETTING: Data from a nationwide COVID-19 cohort database by the Korea National Health Insurance Corporation were used. PARTICIPANTS AND INTERVENTIONS: A total of 8070 patients with COVID-19 (1 January 2020 through 4 June 2020) were matched with 32 280 control participants with regard to age, sex and income. Patients with COVID-19 were confirmed by SARS-CoV-2 PCR and controls were collected from the database. RA was confirmed using the diagnostic code (International Classification of Disease, Tenth Revision) and medication claim codes. Conditional/unconditional logistic regression was applied to analyse the association between RA and COVID-19. PRIMARY OUTCOME AND SECONDARY OUTCOME: Laboratory confirmation of SARS-CoV-2 infection was defined as the primary outcome. The secondary outcome was severe COVID-19 defined as a history of intensive care unit admission, invasive ventilation or death. RESULTS: The prevalence of RA in the COVID-19 (0.4%, 35/8070) and control (0.4%, 121/32,280) groups did not differ (p=0.446). After adjusting for underlying diseases, no association between RA and COVID-19 was observed (adjusted OR=1.14, 95% CI: 0.78 to 1.67) and COVID-19 severity was not associated with RA (adjusted OR=0.62, 95% CI: 0.14 to 7.29). The overall mortality rate was 2.9% (237/8070) and RA was not significantly associated with mortality (adjusted OR=1.64, 95% CI: 0.33 to 8.15). CONCLUSION: We did not find an association between the presence of RA and COVID-19. In addition, RA was not associated with the severity of COVID-19. BMJ Publishing Group 2021-10-07 /pmc/articles/PMC8507409/ /pubmed/34620675 http://dx.doi.org/10.1136/bmjopen-2021-054753 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Infectious Diseases
Jung, Younghee
Kwon, Mihye
Choi, Hyo Geun
Association between previous rheumatoid arthritis and COVID-19 and its severity: a nationwide cohort study in South Korea
title Association between previous rheumatoid arthritis and COVID-19 and its severity: a nationwide cohort study in South Korea
title_full Association between previous rheumatoid arthritis and COVID-19 and its severity: a nationwide cohort study in South Korea
title_fullStr Association between previous rheumatoid arthritis and COVID-19 and its severity: a nationwide cohort study in South Korea
title_full_unstemmed Association between previous rheumatoid arthritis and COVID-19 and its severity: a nationwide cohort study in South Korea
title_short Association between previous rheumatoid arthritis and COVID-19 and its severity: a nationwide cohort study in South Korea
title_sort association between previous rheumatoid arthritis and covid-19 and its severity: a nationwide cohort study in south korea
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507409/
https://www.ncbi.nlm.nih.gov/pubmed/34620675
http://dx.doi.org/10.1136/bmjopen-2021-054753
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