Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants

[Image: see text] Melatonin is a hormone mainly produced by the pineal gland and MT(1) is one of the two G protein-coupled receptors (GPCRs) mediating its action. Despite an increasing number of available GPCR crystal structures, the molecular mechanism of activation of a large number of receptors,...

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Detalles Bibliográficos
Autores principales: Hegron, Alan, Huh, Eunna, Deupi, Xavier, Sokrat, Badr, Gao, Wenwen, Le Gouill, Christian, Canouil, Mickaël, Boissel, Mathilde, Charpentier, Guillaume, Roussel, Ronan, Balkau, Beverley, Froguel, Philippe, Plouffe, Bianca, Bonnefond, Amélie, Lichtarge, Olivier, Jockers, Ralf, Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507577/
https://www.ncbi.nlm.nih.gov/pubmed/34661078
http://dx.doi.org/10.1021/acsptsci.1c00157

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