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The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia

Background: Sinovac was the first vaccine used in Indonesia against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data regarding the effects of certain variables such as clinical demographics on antibody levels in individuals vaccinated with Sinovac are scarce. This study ai...

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Autores principales: Heriyanto, Rivaldo Steven, Kurniawan, Andree, Wijovi, Felix, Halim, Devina Adella, Jodhinata, Claudia, Marcella, Elizabeth, Susanto, Billy, Wibowo, Johan, Indrawan, Michele, Heryadi, Nadia Khoirunnisa, Imanuelly, Michelle, Anurantha, Jonathan Juniard, Hariyanto, Timotius Ivan, Marcellin, Chintya, Sinaga, Terry Devita, Rizki, Saraswati Anindita, Sieto, Novia, Siregar, Jeremia Immanuel, Lugito, Nata Pratama Hardjo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507582/
https://www.ncbi.nlm.nih.gov/pubmed/34653654
http://dx.doi.org/10.1016/j.ijid.2021.10.009
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author Heriyanto, Rivaldo Steven
Kurniawan, Andree
Wijovi, Felix
Halim, Devina Adella
Jodhinata, Claudia
Marcella, Elizabeth
Susanto, Billy
Wibowo, Johan
Indrawan, Michele
Heryadi, Nadia Khoirunnisa
Imanuelly, Michelle
Anurantha, Jonathan Juniard
Hariyanto, Timotius Ivan
Marcellin, Chintya
Sinaga, Terry Devita
Rizki, Saraswati Anindita
Sieto, Novia
Siregar, Jeremia Immanuel
Lugito, Nata Pratama Hardjo
author_facet Heriyanto, Rivaldo Steven
Kurniawan, Andree
Wijovi, Felix
Halim, Devina Adella
Jodhinata, Claudia
Marcella, Elizabeth
Susanto, Billy
Wibowo, Johan
Indrawan, Michele
Heryadi, Nadia Khoirunnisa
Imanuelly, Michelle
Anurantha, Jonathan Juniard
Hariyanto, Timotius Ivan
Marcellin, Chintya
Sinaga, Terry Devita
Rizki, Saraswati Anindita
Sieto, Novia
Siregar, Jeremia Immanuel
Lugito, Nata Pratama Hardjo
author_sort Heriyanto, Rivaldo Steven
collection PubMed
description Background: Sinovac was the first vaccine used in Indonesia against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data regarding the effects of certain variables such as clinical demographics on antibody levels in individuals vaccinated with Sinovac are scarce. This study aimed to investigate the impact of gender and previous SARS-CoV-2 infection status on neutralizing antibody titers 1, 2, and 3 months after administration of the Sinovac vaccine. Method: A cross-sectional study was conducted from February to May 2021. Data on neutralizing antibody levels, previous SARS-CoV-2 infection status, and gender were retrieved from the monthly quantitative serology evaluation database of Siloam Hospitals Lippo Village, Tangerang, Indonesia. The role of each variable was analyzed using the t-test or Mann-Whitney U test, depending on data distribution. Result: Data from 350 participants were collected for the study. Participants with a history of a positive SARS-CoV-2 RT-PCR test had significantly higher neutralizing antibody titers in the first (144 U/mL, p = 0.036) and second months (144 U/mL, p = 0.005) after vaccination compared with those without a history of positive RT-PCR test. Female participants also had significantly higher neutralizing antibody titers in the first, second, and third months (43 U/mL, 42 U/mL, and 39 U/mL, respectively; p = 0.001, p = 0.002, and p = 0.003, respectively) after vaccination compared to males. Conclusion: COVID-19 survivor status and the female gender were associated with higher neutralizing antibody titers after Sinovac vaccine administration.
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spelling pubmed-85075822021-10-13 The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia Heriyanto, Rivaldo Steven Kurniawan, Andree Wijovi, Felix Halim, Devina Adella Jodhinata, Claudia Marcella, Elizabeth Susanto, Billy Wibowo, Johan Indrawan, Michele Heryadi, Nadia Khoirunnisa Imanuelly, Michelle Anurantha, Jonathan Juniard Hariyanto, Timotius Ivan Marcellin, Chintya Sinaga, Terry Devita Rizki, Saraswati Anindita Sieto, Novia Siregar, Jeremia Immanuel Lugito, Nata Pratama Hardjo Int J Infect Dis Article Background: Sinovac was the first vaccine used in Indonesia against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data regarding the effects of certain variables such as clinical demographics on antibody levels in individuals vaccinated with Sinovac are scarce. This study aimed to investigate the impact of gender and previous SARS-CoV-2 infection status on neutralizing antibody titers 1, 2, and 3 months after administration of the Sinovac vaccine. Method: A cross-sectional study was conducted from February to May 2021. Data on neutralizing antibody levels, previous SARS-CoV-2 infection status, and gender were retrieved from the monthly quantitative serology evaluation database of Siloam Hospitals Lippo Village, Tangerang, Indonesia. The role of each variable was analyzed using the t-test or Mann-Whitney U test, depending on data distribution. Result: Data from 350 participants were collected for the study. Participants with a history of a positive SARS-CoV-2 RT-PCR test had significantly higher neutralizing antibody titers in the first (144 U/mL, p = 0.036) and second months (144 U/mL, p = 0.005) after vaccination compared with those without a history of positive RT-PCR test. Female participants also had significantly higher neutralizing antibody titers in the first, second, and third months (43 U/mL, 42 U/mL, and 39 U/mL, respectively; p = 0.001, p = 0.002, and p = 0.003, respectively) after vaccination compared to males. Conclusion: COVID-19 survivor status and the female gender were associated with higher neutralizing antibody titers after Sinovac vaccine administration. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-12 2021-10-12 /pmc/articles/PMC8507582/ /pubmed/34653654 http://dx.doi.org/10.1016/j.ijid.2021.10.009 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Heriyanto, Rivaldo Steven
Kurniawan, Andree
Wijovi, Felix
Halim, Devina Adella
Jodhinata, Claudia
Marcella, Elizabeth
Susanto, Billy
Wibowo, Johan
Indrawan, Michele
Heryadi, Nadia Khoirunnisa
Imanuelly, Michelle
Anurantha, Jonathan Juniard
Hariyanto, Timotius Ivan
Marcellin, Chintya
Sinaga, Terry Devita
Rizki, Saraswati Anindita
Sieto, Novia
Siregar, Jeremia Immanuel
Lugito, Nata Pratama Hardjo
The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_full The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_fullStr The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_full_unstemmed The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_short The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_sort role of covid‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after sinovac vaccine administration on clinical‐year medical students in indonesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507582/
https://www.ncbi.nlm.nih.gov/pubmed/34653654
http://dx.doi.org/10.1016/j.ijid.2021.10.009
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