Binding of Ca(2+)-independent C2 domains to lipid membranes: A multi-scale molecular dynamics study

C2 domains facilitate protein interactions with lipid bilayers in either a Ca(2+)-dependent or -independent manner. We used molecular dynamics (MD) simulations to explore six Ca(2+)-independent C2 domains, from KIBRA, PI3KC2α, RIM2, PTEN, SHIP2, and Smurf2. In coarse-grained MD simulations these C2...

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Detalles Bibliográficos
Autores principales: Larsen, Andreas Haahr, Sansom, Mark S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Theory
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507603/
https://www.ncbi.nlm.nih.gov/pubmed/34081910
http://dx.doi.org/10.1016/j.str.2021.05.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507603/
https://www.ncbi.nlm.nih.gov/pubmed/34081910
http://dx.doi.org/10.1016/j.str.2021.05.011

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