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Binding of Ca(2+)-independent C2 domains to lipid membranes: A multi-scale molecular dynamics study
C2 domains facilitate protein interactions with lipid bilayers in either a Ca(2+)-dependent or -independent manner. We used molecular dynamics (MD) simulations to explore six Ca(2+)-independent C2 domains, from KIBRA, PI3KC2α, RIM2, PTEN, SHIP2, and Smurf2. In coarse-grained MD simulations these C2...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507603/ https://www.ncbi.nlm.nih.gov/pubmed/34081910 http://dx.doi.org/10.1016/j.str.2021.05.011 |