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Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data

Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at b...

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Autores principales: Dipnall, Joanna F., Rivara, Frederick P., Lyons, Ronan A., Ameratunga, Shanthi, Brussoni, Mariana, Lecky, Fiona E., Bradley, Clare, Beck, Ben, Lyons, Jane, Schneeberg, Amy, Harrison, James E., Gabbe, Belinda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507627/
https://www.ncbi.nlm.nih.gov/pubmed/34639458
http://dx.doi.org/10.3390/ijerph181910156
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author Dipnall, Joanna F.
Rivara, Frederick P.
Lyons, Ronan A.
Ameratunga, Shanthi
Brussoni, Mariana
Lecky, Fiona E.
Bradley, Clare
Beck, Ben
Lyons, Jane
Schneeberg, Amy
Harrison, James E.
Gabbe, Belinda J.
author_facet Dipnall, Joanna F.
Rivara, Frederick P.
Lyons, Ronan A.
Ameratunga, Shanthi
Brussoni, Mariana
Lecky, Fiona E.
Bradley, Clare
Beck, Ben
Lyons, Jane
Schneeberg, Amy
Harrison, James E.
Gabbe, Belinda J.
author_sort Dipnall, Joanna F.
collection PubMed
description Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population.
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spelling pubmed-85076272021-10-13 Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data Dipnall, Joanna F. Rivara, Frederick P. Lyons, Ronan A. Ameratunga, Shanthi Brussoni, Mariana Lecky, Fiona E. Bradley, Clare Beck, Ben Lyons, Jane Schneeberg, Amy Harrison, James E. Gabbe, Belinda J. Int J Environ Res Public Health Article Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population. MDPI 2021-09-27 /pmc/articles/PMC8507627/ /pubmed/34639458 http://dx.doi.org/10.3390/ijerph181910156 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dipnall, Joanna F.
Rivara, Frederick P.
Lyons, Ronan A.
Ameratunga, Shanthi
Brussoni, Mariana
Lecky, Fiona E.
Bradley, Clare
Beck, Ben
Lyons, Jane
Schneeberg, Amy
Harrison, James E.
Gabbe, Belinda J.
Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_full Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_fullStr Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_full_unstemmed Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_short Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_sort health-related quality of life (hrqol) outcomes following injury in childhood and adolescence using euroqol (eq-5d) responses with pooled longitudinal data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507627/
https://www.ncbi.nlm.nih.gov/pubmed/34639458
http://dx.doi.org/10.3390/ijerph181910156
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