Cargando…

Targetable Pathways in Advanced Bladder Cancer: FGFR Signaling

SIMPLE SUMMARY: Around 20% of advanced bladder cancer patients carry unfavorable genetic alterations in the fibroblast growth factor receptor 3 (FGFR3) gene. This review summarizes recent findings from published research and clinical trial data focusing on developing and testing therapeutics that in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Jin-Fen, Caliri, Andrew W., Duex, Jason E., Theodorescu, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507635/ https://www.ncbi.nlm.nih.gov/pubmed/34638374 http://dx.doi.org/10.3390/cancers13194891

Ejemplares similares

The Potential of Combination Therapies and Patient Stratification to Improve CCR2 Inhibition Therapeutics
por: Duex, Jason E., et al.
Publicado: (2021)

AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer
por: Agarwal, Neeraj, et al.
Publicado: (2022)

Targeted therapies for advanced bladder cancer: new strategies with FGFR inhibitors
por: Casadei, Chiara, et al.
Publicado: (2019)

ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer
por: di Martino, Erica, et al.
Publicado: (2019)

Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer
por: Weickhardt, Andrew J., et al.
Publicado: (2022)

New Directions and Challenges in Targeted Therapies of Advanced Bladder Cancer: The Role of FGFR Inhibitors
por: Szklener, Katarzyna, et al.
Publicado: (2022)

Characterization of FGFR signaling pathway as therapeutic targets for sarcoma patients
por: Zhou, Wen-Ya, et al.
Publicado: (2016)

Intrinsic FGFR2 and Ectopic FGFR1 Signaling in the Prostate and Prostate Cancer
por: Wang, Cong, et al.
Publicado: (2019)

Tackling FGFR3-driven bladder cancer with a promising synergistic FGFR/HDAC targeted therapy
por: Wang, Zechen, et al.
Publicado: (2023)

Targeting the FGFR signaling pathway in cholangiocarcinoma: promise or delusion?
por: Wang, Jing, et al.
Publicado: (2020)

Robot-Assisted Radical Cystectomy in the Management of Bladder Cancer
por: Keim, Jessica L., et al.
Publicado: (2006)

Deciphering role of FGFR signalling pathway in pancreatic cancer
por: Kang, Xiaodiao, et al.
Publicado: (2019)

Current progress in cancer treatment by targeting FGFR signaling
por: Du, Sicheng, et al.
Publicado: (2023)

RhoGDI2 suppresses bladder cancer metastasis via reduction of inflammation in the tumor microenvironment
por: Said, Neveen, et al.
Publicado: (2012)

Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations
por: Lima, Nadia Carvalho, et al.
Publicado: (2020)

Oncogenic FGFR3 gene fusions in bladder cancer
por: Williams, Sarah V., et al.
Publicado: (2013)

FGFR Pathway Inhibition in Gastric Cancer: The Golden Era of an Old Target?
por: Lengyel, Csongor G., et al.
Publicado: (2022)

Targeting FGFR Pathways in Gastrointestinal Cancers: New Frontiers of Treatment
por: Ratti, Margherita, et al.
Publicado: (2023)

A Gene Expression Signature Predicts Bladder Cancer Cell Line Sensitivity to EGFR Inhibition
por: Goodspeed, Andrew, et al.
Publicado: (2018)

The Prognostic Value of Cell Cycle Gene Expression Signatures in Muscle Invasive, High-Grade Bladder Cancer
por: Dancik, Garrett M., et al.
Publicado: (2015)

Robust Prognostic Gene Expression Signatures in Bladder Cancer and Lung Adenocarcinoma Depend on Cell Cycle Related Genes
por: Dancik, Garrett M., et al.
Publicado: (2014)

miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer
por: Nordentoft, Iver, et al.
Publicado: (2012)

FGFR3 Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer
por: Kacew, Alec, et al.
Publicado: (2020)

Analysis of FGFR3 and HRAS genes in patients with bladder cancer
por: Homami, Ameneh, et al.
Publicado: (2020)

Significance of the FGFR3 mutation in Chinese patients with bladder cancer
por: Hao, Lanxiang, et al.
Publicado: (2023)

Molecular markers in transitional cell carcinoma of the bladder: New insights into mechanisms and prognosis
por: Ehdaie, Behfar, et al.
Publicado: (2008)

A 20 gene model for predicting nodal involvement in bladder cancer patients with muscle invasive tumors
por: Dancik, Garrett, et al.
Publicado: (2011)

FGF/FGFR signaling pathway involved resistance in various cancer types
por: Zhou, Yangyang, et al.
Publicado: (2020)

Identifying novel biomarkers associated with bladder cancer treatment outcomes
por: Castaneda, Peris R., et al.
Publicado: (2023)

Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models
por: Zhang, H, et al.
Publicado: (2014)

High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes
por: Rinaldetti, Sébastien, et al.
Publicado: (2022)

Mechanism of Sex Differences in Bladder Cancer: Evident and Elusive Sex-biasing Factors
por: Lam, Christa M., et al.
Publicado: (2022)

FGFR(3S249C) mutation promotes chemoresistance by activating Akt signaling in bladder cancer cells
por: Xie, Xina, et al.
Publicado: (2019)

An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers
por: Mahe, Mélanie, et al.
Publicado: (2018)

Role of Bladder Cancer Metabolic Reprogramming in the Effectiveness of Immunotherapy
por: Scholtes, Mathijs P., et al.
Publicado: (2021)

Targeted Therapies in Advanced Cholangiocarcinoma: A Focus on FGFR Inhibitors
por: Rizzo, Alessandro
Publicado: (2021)

FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder
por: Guancial, Elizabeth A, et al.
Publicado: (2014)

FGFR1 Induces Acquired Resistance Against Gefitinib By Activating AKT/mTOR Pathway In NSCLC
por: Zhang, Dan, et al.
Publicado: (2019)

Molecular Biomarkers of Response to PD-1/ PD-L1 Immune Checkpoint Blockade in Advanced Bladder Cancer(1)
por: Tu, Megan M., et al.
Publicado: (2019)

Complexity of FGFR signalling in metastatic urothelial cancer
por: Rodriguez-Vida, Alejo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_thu2v5tjaa2e053mvbp2li5doo