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Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010
Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to ide...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507643/ https://www.ncbi.nlm.nih.gov/pubmed/34639548 http://dx.doi.org/10.3390/ijerph181910249 |
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author | Wan, En-Tzu Darssan, Darsy Karatela, Shamshad Reid, Simon A. Osborne, Nicholas John |
author_facet | Wan, En-Tzu Darssan, Darsy Karatela, Shamshad Reid, Simon A. Osborne, Nicholas John |
author_sort | Wan, En-Tzu |
collection | PubMed |
description | Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to identify a pathological pathway. We pooled data from four cross-sectional waves of NHANES, with 41,847 participants in total. Exposure to malathion increased the risk of low kidney function (aOR = 1.26, 95% CI = 1.01–1.56) in the adjusted model. Increased risk of low kidney function was not found among those exposed to 2,4-D (aOR = 0.88, 95% CI = 0.72–1.09), 3,5,6-trichloropyridinol (aOR = 0.96, 95% CI = 0.83–1.12), and 3-PBA (aOR = 1.03, 95% CI = 0.94–1.13). Our findings provide evidence of altered kidney function in people exposed to malathion, highlighting the potential of organophosphate pesticides’ role in renal injury. |
format | Online Article Text |
id | pubmed-8507643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85076432021-10-13 Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010 Wan, En-Tzu Darssan, Darsy Karatela, Shamshad Reid, Simon A. Osborne, Nicholas John Int J Environ Res Public Health Article Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to identify a pathological pathway. We pooled data from four cross-sectional waves of NHANES, with 41,847 participants in total. Exposure to malathion increased the risk of low kidney function (aOR = 1.26, 95% CI = 1.01–1.56) in the adjusted model. Increased risk of low kidney function was not found among those exposed to 2,4-D (aOR = 0.88, 95% CI = 0.72–1.09), 3,5,6-trichloropyridinol (aOR = 0.96, 95% CI = 0.83–1.12), and 3-PBA (aOR = 1.03, 95% CI = 0.94–1.13). Our findings provide evidence of altered kidney function in people exposed to malathion, highlighting the potential of organophosphate pesticides’ role in renal injury. MDPI 2021-09-29 /pmc/articles/PMC8507643/ /pubmed/34639548 http://dx.doi.org/10.3390/ijerph181910249 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wan, En-Tzu Darssan, Darsy Karatela, Shamshad Reid, Simon A. Osborne, Nicholas John Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010 |
title | Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010 |
title_full | Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010 |
title_fullStr | Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010 |
title_full_unstemmed | Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010 |
title_short | Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010 |
title_sort | association of pesticides and kidney function among adults in the us population 2001–2010 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507643/ https://www.ncbi.nlm.nih.gov/pubmed/34639548 http://dx.doi.org/10.3390/ijerph181910249 |
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