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Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010

Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to ide...

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Autores principales: Wan, En-Tzu, Darssan, Darsy, Karatela, Shamshad, Reid, Simon A., Osborne, Nicholas John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507643/
https://www.ncbi.nlm.nih.gov/pubmed/34639548
http://dx.doi.org/10.3390/ijerph181910249
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author Wan, En-Tzu
Darssan, Darsy
Karatela, Shamshad
Reid, Simon A.
Osborne, Nicholas John
author_facet Wan, En-Tzu
Darssan, Darsy
Karatela, Shamshad
Reid, Simon A.
Osborne, Nicholas John
author_sort Wan, En-Tzu
collection PubMed
description Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to identify a pathological pathway. We pooled data from four cross-sectional waves of NHANES, with 41,847 participants in total. Exposure to malathion increased the risk of low kidney function (aOR = 1.26, 95% CI = 1.01–1.56) in the adjusted model. Increased risk of low kidney function was not found among those exposed to 2,4-D (aOR = 0.88, 95% CI = 0.72–1.09), 3,5,6-trichloropyridinol (aOR = 0.96, 95% CI = 0.83–1.12), and 3-PBA (aOR = 1.03, 95% CI = 0.94–1.13). Our findings provide evidence of altered kidney function in people exposed to malathion, highlighting the potential of organophosphate pesticides’ role in renal injury.
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spelling pubmed-85076432021-10-13 Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010 Wan, En-Tzu Darssan, Darsy Karatela, Shamshad Reid, Simon A. Osborne, Nicholas John Int J Environ Res Public Health Article Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to identify a pathological pathway. We pooled data from four cross-sectional waves of NHANES, with 41,847 participants in total. Exposure to malathion increased the risk of low kidney function (aOR = 1.26, 95% CI = 1.01–1.56) in the adjusted model. Increased risk of low kidney function was not found among those exposed to 2,4-D (aOR = 0.88, 95% CI = 0.72–1.09), 3,5,6-trichloropyridinol (aOR = 0.96, 95% CI = 0.83–1.12), and 3-PBA (aOR = 1.03, 95% CI = 0.94–1.13). Our findings provide evidence of altered kidney function in people exposed to malathion, highlighting the potential of organophosphate pesticides’ role in renal injury. MDPI 2021-09-29 /pmc/articles/PMC8507643/ /pubmed/34639548 http://dx.doi.org/10.3390/ijerph181910249 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wan, En-Tzu
Darssan, Darsy
Karatela, Shamshad
Reid, Simon A.
Osborne, Nicholas John
Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010
title Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010
title_full Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010
title_fullStr Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010
title_full_unstemmed Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010
title_short Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010
title_sort association of pesticides and kidney function among adults in the us population 2001–2010
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507643/
https://www.ncbi.nlm.nih.gov/pubmed/34639548
http://dx.doi.org/10.3390/ijerph181910249
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