Cargando…

Using Organotypic Tissue Slices to Investigate the Microenvironment of Pancreatic Cancer: Pharmacotyping and Beyond

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) has the highest mortality rate of all major cancers and, disappointingly, neither immune- nor stroma-directed therapies are found to improve upon the current standard of care. Among the most challenging aspects of PDAC biology which impede clin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weitz, Jonathan Robert, Tiriac, Herve, Hurtado de Mendoza, Tatiana, Wascher, Alexis, Lowy, Andrew M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507648/ https://www.ncbi.nlm.nih.gov/pubmed/34638476 http://dx.doi.org/10.3390/cancers13194991

Ejemplares similares

Pancreatic Ductal Adenocarcinoma Induces Neural Injury that Promotes a Transcriptomic and Functional Repair Signature by Peripheral Neuroglia
por: Weitz, Jonathan, et al.
Publicado: (2023)

An Organotypic Microcosm for the Pancreatic Tumor Microenvironment
por: Lin, Miranda, et al.
Publicado: (2020)

Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response
por: Lee, Shawn H. R., et al.
Publicado: (2023)

Characterization and Optimization of the Tumor Microenvironment in Patient-Derived Organotypic Slices and Organoid Models of Glioblastoma
por: Nickl, Vera, et al.
Publicado: (2023)

Recent advances in organotypic tissue slice cultures for anticancer drug development
por: He, Lin, et al.
Publicado: (2022)

ORGANOTYPIC BRAIN SLICE CULTURES: A REVIEW
por: HUMPEL, C.
Publicado: (2015)

CD40 Agonists Alter the Pancreatic Cancer Microenvironment by Shifting the Macrophage Phenotype toward M1 and Suppress Human Pancreatic Cancer in Organotypic Slice Cultures
por: Lim, Chae Yoon, et al.
Publicado: (2022)

Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures
por: Korde, Dhwani S., et al.
Publicado: (2022)

Organotypic slice culture of the hypothalamic paraventricular nucleus of rat
por: Cho, Eun Seong, et al.
Publicado: (2007)

Organotypic brain slice cultures to model neurodegenerative proteinopathies
por: Croft, C. L., et al.
Publicado: (2019)

Microcontact Printing of Cholinergic Neurons in Organotypic Brain Slices
por: Steiner, Katharina, et al.
Publicado: (2021)

Organotypic hippocampal slices, an emerging tool to model synucleinopathies
por: Elfarrash, Sara, et al.
Publicado: (2020)

Organotypic Cerebellar Cultures: Apoptotic Challenges and Detection
por: Hurtado de Mendoza, Tatiana, et al.
Publicado: (2011)

Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma
por: Misra, Sougat, et al.
Publicado: (2019)

Organotypic Spinal Cord Slice Culture to Study Neural Stem/Progenitor Cell Microenvironment in the Injured Spinal Cord
por: Kim, Hyuk Min, et al.
Publicado: (2010)

Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures
por: Falsig, Jeppe, et al.
Publicado: (2012)

Neuroprotective effects of mild hypoxia in organotypic hippocampal slice cultures
por: Kim, Seh Hyun, et al.
Publicado: (2015)

Persistent Gliosis Interferes with Neurogenesis in Organotypic Hippocampal Slice Cultures
por: Gerlach, Johannes, et al.
Publicado: (2016)

Organotypic slice cultures of human gastric and esophagogastric junction cancer
por: Koerfer, Justus, et al.
Publicado: (2016)

Preparation of organotypic brain slice cultures for the study of Alzheimer’s disease
por: Croft, Cara L., et al.
Publicado: (2018)

The Impact of Chemical Fixation on the Microanatomy of Mouse Organotypic Hippocampal Slices
por: Idziak, Agata, et al.
Publicado: (2023)

Slice Preparation, Organotypic Tissue Culturing and Luciferase Recording of Clock Gene Activity in the Suprachiasmatic Nucleus
por: Savelyev, Sergey A., et al.
Publicado: (2011)

The Biological Behaviors of Neural Stem Cell Affected by Microenvironment from Host Organotypic Brain Slices under Different Conditions
por: Jiao, Qian, et al.
Publicado: (2023)

Correlation of in vitro infiltration with glioma histological type in organotypic brain slices
por: Palfi, S, et al.
Publicado: (2004)

Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments
por: Merz, Felicitas, et al.
Publicado: (2013)

Single-cell mechanics and calcium signalling in organotypic slices of human myometrium()
por: Loftus, Fiona C., et al.
Publicado: (2015)

The Organotypic Longitudinal Spinal Cord Slice Culture for Stem Cell Study
por: Sypecka, Joanna, et al.
Publicado: (2015)

An organotypic slice culture to study the formation of calyx of Held synapses in-vitro
por: Kronander, Elin, et al.
Publicado: (2017)

A hierarchy of manganese competition and entry in organotypic hippocampal slice cultures
por: Petrus, Emily, et al.
Publicado: (2021)

Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices
por: Uçar, Buket, et al.
Publicado: (2022)

Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions
por: Liu, Yingjun, et al.
Publicado: (2022)

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis
por: Shen, Joanne X., et al.
Publicado: (2021)

Coculture System with an Organotypic Brain Slice and 3D Spheroid of Carcinoma Cells
por: Chuang, Han-Ning, et al.
Publicado: (2013)

Organotypic brain slice cultures as a model to study angiogenesis of brain vessels
por: Hutter-Schmid, Bianca, et al.
Publicado: (2015)

An advanced glioma cell invasion assay based on organotypic brain slice cultures
por: Eisemann, Tanja, et al.
Publicado: (2018)

Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures
por: Gargouri, Brahim, et al.
Publicado: (2018)

Acute death of astrocytes in blast-exposed rat organotypic hippocampal slice cultures
por: Miller, Anna P., et al.
Publicado: (2017)

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture
por: Hoyle, Christopher, et al.
Publicado: (2020)

POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research
por: Pineau, Hailey, et al.
Publicado: (2020)

Ex Vivo Recording of Axonal Transport Dynamics on Postnatal Organotypic Cortical Slices
por: Turchetto, Silvia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rdl9lak9io69qle27pp1puoeea