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Risk Factors for Apathy in Polish Patients with Parkinson’s Disease

Apathy, a feeling of indifference or a general lack of interest and motivation to engage in activity, is one of the most common neuropsychiatric symptoms in Parkinson’s disease (PD). The large variation in prevalence and the underlying pathophysiological processes remain unclear due to heterogeneous...

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Autores principales: Gorzkowska, Agnieszka, Cholewa, Joanna, Cholewa, Jaroslaw, Wilk, Aleksander, Klimkowicz-Mrowiec, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507785/
https://www.ncbi.nlm.nih.gov/pubmed/34639517
http://dx.doi.org/10.3390/ijerph181910196
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author Gorzkowska, Agnieszka
Cholewa, Joanna
Cholewa, Jaroslaw
Wilk, Aleksander
Klimkowicz-Mrowiec, Aleksandra
author_facet Gorzkowska, Agnieszka
Cholewa, Joanna
Cholewa, Jaroslaw
Wilk, Aleksander
Klimkowicz-Mrowiec, Aleksandra
author_sort Gorzkowska, Agnieszka
collection PubMed
description Apathy, a feeling of indifference or a general lack of interest and motivation to engage in activity, is one of the most common neuropsychiatric symptoms in Parkinson’s disease (PD). The large variation in prevalence and the underlying pathophysiological processes remain unclear due to heterogeneous PD populations. The purpose of this study was to identify risk factors for apathy, the modification or treatment of which may be clinically relevant and improve quality of life and caregiver burden for patients with Parkinson’s disease. Caucasian subjects with Parkinson’s disease were included in the study. Baseline demographics, neurological deficit, medications taken, cognitive and neuropsychiatric status, and the polymorphisms in the brain-derived neurotrophic factor gene were assessed. Apathy was diagnosed in 53 (50.5%) patients. They were less educated (OR 0.76 CI 0.64–0.89; p = 0.001), more frequently depressed (OR 1.08 CI 1.01–1.15; p = 0.018), and less frequently treated with inhibitors of monoamine oxidase-B (MAOB-I) (OR 0.07 CI 0.01–0.69; p = 0.023). Although apathetic patients were more likely to carry the Met/Met genotype, differences in the brain-derived neurotrophic factor BDNF rs6265 polymorphism between apathetic and non-apathetic PD patients were not statistically significant in multivariate analysis. Some risk factors for apathy may be clinically modifiable. Further studies are needed to assess whether modeling modifiable apathy risk factors will affect the prevalence of this neuropsychiatric symptom in patients with Parkinson’s disease.
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spelling pubmed-85077852021-10-13 Risk Factors for Apathy in Polish Patients with Parkinson’s Disease Gorzkowska, Agnieszka Cholewa, Joanna Cholewa, Jaroslaw Wilk, Aleksander Klimkowicz-Mrowiec, Aleksandra Int J Environ Res Public Health Article Apathy, a feeling of indifference or a general lack of interest and motivation to engage in activity, is one of the most common neuropsychiatric symptoms in Parkinson’s disease (PD). The large variation in prevalence and the underlying pathophysiological processes remain unclear due to heterogeneous PD populations. The purpose of this study was to identify risk factors for apathy, the modification or treatment of which may be clinically relevant and improve quality of life and caregiver burden for patients with Parkinson’s disease. Caucasian subjects with Parkinson’s disease were included in the study. Baseline demographics, neurological deficit, medications taken, cognitive and neuropsychiatric status, and the polymorphisms in the brain-derived neurotrophic factor gene were assessed. Apathy was diagnosed in 53 (50.5%) patients. They were less educated (OR 0.76 CI 0.64–0.89; p = 0.001), more frequently depressed (OR 1.08 CI 1.01–1.15; p = 0.018), and less frequently treated with inhibitors of monoamine oxidase-B (MAOB-I) (OR 0.07 CI 0.01–0.69; p = 0.023). Although apathetic patients were more likely to carry the Met/Met genotype, differences in the brain-derived neurotrophic factor BDNF rs6265 polymorphism between apathetic and non-apathetic PD patients were not statistically significant in multivariate analysis. Some risk factors for apathy may be clinically modifiable. Further studies are needed to assess whether modeling modifiable apathy risk factors will affect the prevalence of this neuropsychiatric symptom in patients with Parkinson’s disease. MDPI 2021-09-28 /pmc/articles/PMC8507785/ /pubmed/34639517 http://dx.doi.org/10.3390/ijerph181910196 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gorzkowska, Agnieszka
Cholewa, Joanna
Cholewa, Jaroslaw
Wilk, Aleksander
Klimkowicz-Mrowiec, Aleksandra
Risk Factors for Apathy in Polish Patients with Parkinson’s Disease
title Risk Factors for Apathy in Polish Patients with Parkinson’s Disease
title_full Risk Factors for Apathy in Polish Patients with Parkinson’s Disease
title_fullStr Risk Factors for Apathy in Polish Patients with Parkinson’s Disease
title_full_unstemmed Risk Factors for Apathy in Polish Patients with Parkinson’s Disease
title_short Risk Factors for Apathy in Polish Patients with Parkinson’s Disease
title_sort risk factors for apathy in polish patients with parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507785/
https://www.ncbi.nlm.nih.gov/pubmed/34639517
http://dx.doi.org/10.3390/ijerph181910196
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