Cargando…

Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot

Aim: This study evaluates the risk factors associated with right ventricular (RV) dilation and dysfunction leading to pulmonary valve replacement (PVR) or adverse cardiac events in repaired Tetralogy of Fallot (rToF) patients. Methods: Data from all rToF patients who underwent magnetic resonance ima...

Descripción completa

Detalles Bibliográficos
Autores principales: Leonardi, Benedetta, Calvieri, Camilla, Perrone, Marco Alfonso, Di Rocco, Arianna, Carotti, Adriano, Caputo, Massimo, Secinaro, Aurelio, Curione, Davide, Gagliardi, Maria Giulia, Guccione, Paolo, Albanese, Sonia, Galletti, Lorenzo, Drago, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507852/
https://www.ncbi.nlm.nih.gov/pubmed/34639849
http://dx.doi.org/10.3390/ijerph181910549
_version_ 1784581957629247488
author Leonardi, Benedetta
Calvieri, Camilla
Perrone, Marco Alfonso
Di Rocco, Arianna
Carotti, Adriano
Caputo, Massimo
Secinaro, Aurelio
Curione, Davide
Gagliardi, Maria Giulia
Guccione, Paolo
Albanese, Sonia
Galletti, Lorenzo
Drago, Fabrizio
author_facet Leonardi, Benedetta
Calvieri, Camilla
Perrone, Marco Alfonso
Di Rocco, Arianna
Carotti, Adriano
Caputo, Massimo
Secinaro, Aurelio
Curione, Davide
Gagliardi, Maria Giulia
Guccione, Paolo
Albanese, Sonia
Galletti, Lorenzo
Drago, Fabrizio
author_sort Leonardi, Benedetta
collection PubMed
description Aim: This study evaluates the risk factors associated with right ventricular (RV) dilation and dysfunction leading to pulmonary valve replacement (PVR) or adverse cardiac events in repaired Tetralogy of Fallot (rToF) patients. Methods: Data from all rToF patients who underwent magnetic resonance imaging (MRI) evaluation at our hospital between February 2007 and September 2020 were collected. Results: Three hundred and forty-two patients (60% males, 42% older than 18 years), with a median age of 16 years (IQR 13–24) at the time of MRI, were included. All patients underwent complete repair at a median age of 8 months (IQR 5–16), while palliation was performed in 56 patients (16%). One hundred and forty-four patients (42%) subsequently received pulmonary valve replacement (PVR). At the multivariate analysis, male gender was an independent predictor for significant RV dilation, RV and left ventricular (LV) dysfunction. Transventricular ventricular septal defect (VSD) closure and previous palliation significantly affected LV function and RV size, respectively. Male gender and the transventricular VSD closure were independent predictors for PVR. Conclusions: Male gender and surgical history (palliation, VSD closure approach) significantly affected the long-term outcomes in rToF patients and should be taken into consideration in the follow-up management and in PVR timing in this patient population.
format Online
Article
Text
id pubmed-8507852
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85078522021-10-13 Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot Leonardi, Benedetta Calvieri, Camilla Perrone, Marco Alfonso Di Rocco, Arianna Carotti, Adriano Caputo, Massimo Secinaro, Aurelio Curione, Davide Gagliardi, Maria Giulia Guccione, Paolo Albanese, Sonia Galletti, Lorenzo Drago, Fabrizio Int J Environ Res Public Health Article Aim: This study evaluates the risk factors associated with right ventricular (RV) dilation and dysfunction leading to pulmonary valve replacement (PVR) or adverse cardiac events in repaired Tetralogy of Fallot (rToF) patients. Methods: Data from all rToF patients who underwent magnetic resonance imaging (MRI) evaluation at our hospital between February 2007 and September 2020 were collected. Results: Three hundred and forty-two patients (60% males, 42% older than 18 years), with a median age of 16 years (IQR 13–24) at the time of MRI, were included. All patients underwent complete repair at a median age of 8 months (IQR 5–16), while palliation was performed in 56 patients (16%). One hundred and forty-four patients (42%) subsequently received pulmonary valve replacement (PVR). At the multivariate analysis, male gender was an independent predictor for significant RV dilation, RV and left ventricular (LV) dysfunction. Transventricular ventricular septal defect (VSD) closure and previous palliation significantly affected LV function and RV size, respectively. Male gender and the transventricular VSD closure were independent predictors for PVR. Conclusions: Male gender and surgical history (palliation, VSD closure approach) significantly affected the long-term outcomes in rToF patients and should be taken into consideration in the follow-up management and in PVR timing in this patient population. MDPI 2021-10-08 /pmc/articles/PMC8507852/ /pubmed/34639849 http://dx.doi.org/10.3390/ijerph181910549 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leonardi, Benedetta
Calvieri, Camilla
Perrone, Marco Alfonso
Di Rocco, Arianna
Carotti, Adriano
Caputo, Massimo
Secinaro, Aurelio
Curione, Davide
Gagliardi, Maria Giulia
Guccione, Paolo
Albanese, Sonia
Galletti, Lorenzo
Drago, Fabrizio
Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot
title Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot
title_full Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot
title_fullStr Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot
title_full_unstemmed Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot
title_short Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot
title_sort risk factors of right ventricular dysfunction and adverse cardiac events in patients with repaired tetralogy of fallot
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507852/
https://www.ncbi.nlm.nih.gov/pubmed/34639849
http://dx.doi.org/10.3390/ijerph181910549
work_keys_str_mv AT leonardibenedetta riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT calviericamilla riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT perronemarcoalfonso riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT diroccoarianna riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT carottiadriano riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT caputomassimo riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT secinaroaurelio riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT curionedavide riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT gagliardimariagiulia riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT guccionepaolo riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT albanesesonia riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT gallettilorenzo riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot
AT dragofabrizio riskfactorsofrightventriculardysfunctionandadversecardiaceventsinpatientswithrepairedtetralogyoffallot