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Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot
Aim: This study evaluates the risk factors associated with right ventricular (RV) dilation and dysfunction leading to pulmonary valve replacement (PVR) or adverse cardiac events in repaired Tetralogy of Fallot (rToF) patients. Methods: Data from all rToF patients who underwent magnetic resonance ima...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507852/ https://www.ncbi.nlm.nih.gov/pubmed/34639849 http://dx.doi.org/10.3390/ijerph181910549 |
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author | Leonardi, Benedetta Calvieri, Camilla Perrone, Marco Alfonso Di Rocco, Arianna Carotti, Adriano Caputo, Massimo Secinaro, Aurelio Curione, Davide Gagliardi, Maria Giulia Guccione, Paolo Albanese, Sonia Galletti, Lorenzo Drago, Fabrizio |
author_facet | Leonardi, Benedetta Calvieri, Camilla Perrone, Marco Alfonso Di Rocco, Arianna Carotti, Adriano Caputo, Massimo Secinaro, Aurelio Curione, Davide Gagliardi, Maria Giulia Guccione, Paolo Albanese, Sonia Galletti, Lorenzo Drago, Fabrizio |
author_sort | Leonardi, Benedetta |
collection | PubMed |
description | Aim: This study evaluates the risk factors associated with right ventricular (RV) dilation and dysfunction leading to pulmonary valve replacement (PVR) or adverse cardiac events in repaired Tetralogy of Fallot (rToF) patients. Methods: Data from all rToF patients who underwent magnetic resonance imaging (MRI) evaluation at our hospital between February 2007 and September 2020 were collected. Results: Three hundred and forty-two patients (60% males, 42% older than 18 years), with a median age of 16 years (IQR 13–24) at the time of MRI, were included. All patients underwent complete repair at a median age of 8 months (IQR 5–16), while palliation was performed in 56 patients (16%). One hundred and forty-four patients (42%) subsequently received pulmonary valve replacement (PVR). At the multivariate analysis, male gender was an independent predictor for significant RV dilation, RV and left ventricular (LV) dysfunction. Transventricular ventricular septal defect (VSD) closure and previous palliation significantly affected LV function and RV size, respectively. Male gender and the transventricular VSD closure were independent predictors for PVR. Conclusions: Male gender and surgical history (palliation, VSD closure approach) significantly affected the long-term outcomes in rToF patients and should be taken into consideration in the follow-up management and in PVR timing in this patient population. |
format | Online Article Text |
id | pubmed-8507852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85078522021-10-13 Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot Leonardi, Benedetta Calvieri, Camilla Perrone, Marco Alfonso Di Rocco, Arianna Carotti, Adriano Caputo, Massimo Secinaro, Aurelio Curione, Davide Gagliardi, Maria Giulia Guccione, Paolo Albanese, Sonia Galletti, Lorenzo Drago, Fabrizio Int J Environ Res Public Health Article Aim: This study evaluates the risk factors associated with right ventricular (RV) dilation and dysfunction leading to pulmonary valve replacement (PVR) or adverse cardiac events in repaired Tetralogy of Fallot (rToF) patients. Methods: Data from all rToF patients who underwent magnetic resonance imaging (MRI) evaluation at our hospital between February 2007 and September 2020 were collected. Results: Three hundred and forty-two patients (60% males, 42% older than 18 years), with a median age of 16 years (IQR 13–24) at the time of MRI, were included. All patients underwent complete repair at a median age of 8 months (IQR 5–16), while palliation was performed in 56 patients (16%). One hundred and forty-four patients (42%) subsequently received pulmonary valve replacement (PVR). At the multivariate analysis, male gender was an independent predictor for significant RV dilation, RV and left ventricular (LV) dysfunction. Transventricular ventricular septal defect (VSD) closure and previous palliation significantly affected LV function and RV size, respectively. Male gender and the transventricular VSD closure were independent predictors for PVR. Conclusions: Male gender and surgical history (palliation, VSD closure approach) significantly affected the long-term outcomes in rToF patients and should be taken into consideration in the follow-up management and in PVR timing in this patient population. MDPI 2021-10-08 /pmc/articles/PMC8507852/ /pubmed/34639849 http://dx.doi.org/10.3390/ijerph181910549 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Leonardi, Benedetta Calvieri, Camilla Perrone, Marco Alfonso Di Rocco, Arianna Carotti, Adriano Caputo, Massimo Secinaro, Aurelio Curione, Davide Gagliardi, Maria Giulia Guccione, Paolo Albanese, Sonia Galletti, Lorenzo Drago, Fabrizio Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot |
title | Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot |
title_full | Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot |
title_fullStr | Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot |
title_full_unstemmed | Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot |
title_short | Risk Factors of Right Ventricular Dysfunction and Adverse Cardiac Events in Patients with Repaired Tetralogy of Fallot |
title_sort | risk factors of right ventricular dysfunction and adverse cardiac events in patients with repaired tetralogy of fallot |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507852/ https://www.ncbi.nlm.nih.gov/pubmed/34639849 http://dx.doi.org/10.3390/ijerph181910549 |
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