Cargando…

Proteomic Characterization of the Cellular Effects of AhR Activation by Microbial Tryptophan Catabolites in Endotoxin-Activated Human Macrophages

Sensing microbial tryptophan catabolites by the aryl hydrocarbon receptor (AhR) plays a pivotal role in host-microbiome homeostasis by modulating the host immune response. Nevertheless, the involved cellular processes triggered by the metabolites are mainly unknown. Here, we analyzed proteomic chang...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walter, Katharina, Grosskopf, Henning, Karkossa, Isabel, von Bergen, Martin, Schubert, Kristin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507890/ https://www.ncbi.nlm.nih.gov/pubmed/34639632 http://dx.doi.org/10.3390/ijerph181910336

Ejemplares similares

Non-Genomic AhR-Signaling Modulates the Immune Response in Endotoxin-Activated Macrophages After Activation by the Environmental Stressor BaP
por: Großkopf, Henning, et al.
Publicado: (2021)

Tryptophan Feeding of the IDO1-AhR Axis in Host–Microbial Symbiosis
por: Zelante, Teresa, et al.
Publicado: (2014)

Microbial tryptophan catabolites in health and disease
por: Roager, Henrik M., et al.
Publicado: (2018)

Tryptophan Supplementation Increases the Production of Microbial-Derived AhR Agonists in an In Vitro Simulator of Intestinal Microbial Ecosystem
por: Koper, Jonna EB, et al.
Publicado: (2022)

Pharmaceutically Active Microbial AhR Agonists as Innovative Biodrugs in Inflammation
por: Puccetti, Matteo, et al.
Publicado: (2022)

Oxidation is an underappreciated post-translational modification in the regulation of immune responses associated with changes in phosphorylation
por: Karkossa, Isabel, et al.
Publicado: (2023)

The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions
por: Gargaro, Marco, et al.
Publicado: (2021)

The Gut Microbiota Activates AhR Through the Tryptophan Metabolite Kyn to Mediate Renal Cell Carcinoma Metastasis
por: Dai, Guoyu, et al.
Publicado: (2021)

Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation
por: Madella, Avra Melina, et al.
Publicado: (2022)

Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands
por: Manzella, Christopher R., et al.
Publicado: (2020)

Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota
por: Salminen, Antero
Publicado: (2023)

AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity
por: Bourner, Luke A., et al.
Publicado: (2022)

AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives
por: Turski, Waldemar A., et al.
Publicado: (2020)

Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation
por: Nguyen, Phuc-Tan, et al.
Publicado: (2023)

UVB Radiation and Selected Tryptophan-Derived AhR Ligands—Potential Biological Interactions in Melanoma Cells
por: Walczak, Katarzyna, et al.
Publicado: (2021)

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation
por: Morgan, Ethan W, et al.
Publicado: (2023)

Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer
por: Elson, Daniel J., et al.
Publicado: (2023)

A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes
por: Szelest, Monika, et al.
Publicado: (2021)

AhR transcriptional activity in serum of Inuits across Greenlandic districts
por: Long, Manhai, et al.
Publicado: (2007)

Coactivator Recruitment of AhR/ARNT1
por: Endler, Alexander, et al.
Publicado: (2014)

AhR signaling pathways and regulatory functions
por: Larigot, Lucie, et al.
Publicado: (2018)

Epigenetic Regulations of AhR in the Aspect of Immunomodulation
por: Wajda, Anna, et al.
Publicado: (2020)

Turning Microbial AhR Agonists into Therapeutic Agents via Drug Delivery Systems
por: Puccetti, Matteo, et al.
Publicado: (2023)

Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis
por: Hebbrecht, Kaat, et al.
Publicado: (2021)

Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia
por: Jasim, Zainab Abdulameer, et al.
Publicado: (2023)

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases
por: Zgheib, Elias, et al.
Publicado: (2018)

Excretion of polybrominated diphenyl ethers and AhR activation in breastmilk among firefighters
por: Jung, Alesia M, et al.
Publicado: (2023)

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization
por: Vyhlídalová, Barbora, et al.
Publicado: (2020)

Akkermansia muciniphila inhibits tryptophan metabolism via the AhR/β-catenin signaling pathway to counter the progression of colorectal cancer
por: Zhang, Lu, et al.
Publicado: (2023)

Role of AhR/ARNT system in skin homeostasis
por: Furue, Masutaka, et al.
Publicado: (2014)

Bidirectional talk between AhR and Oct4
por: Kang, Bo, et al.
Publicado: (2015)

Induction of AhR-Mediated Gene Transcription by Coffee
por: Ishikawa, Toshio, et al.
Publicado: (2014)

New Treatments in Renal Cancer: The AhR Ligands
por: Itkin, Boris, et al.
Publicado: (2020)

Herbal Plants: The Role of AhR in Mediating Immunomodulation
por: Bungsu, Izzah, et al.
Publicado: (2021)

Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndrome
por: Shang, Haitao, et al.
Publicado: (2023)

Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR
por: Medjakovic, Svjetlana, et al.
Publicado: (2010)

The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90
por: Tsuji, Noriko, et al.
Publicado: (2014)

AhR activation underlies the CYP1A autoinduction by A-998679 in rats
por: Liguori, Michael J., et al.
Publicado: (2012)

Corrigendum: Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases
por: Zgheib, Elias, et al.
Publicado: (2019)

AhR activation defends gut barrier integrity against damage occurring in obesity
por: Postal, Bárbara G., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_eruk1s8kk7jn71jktdlpcaag5s