Cargando…
Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study
Bisphenols are endocrine disruptors that may be associated with altered fetal growth in humans, and they have similar biological functions to mimic hormones. In addition, aggregated chemicals showed an adverse effect although individual concentration was at a low level. However, most studies between...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508042/ https://www.ncbi.nlm.nih.gov/pubmed/34639400 http://dx.doi.org/10.3390/ijerph181910098 |
_version_ | 1784582004616986624 |
---|---|
author | Kim, Seyoung Park, Eunjung Park, Eun-Kyo Lee, Seulbi Kwon, Jeoung-A Shin, Bo-Hye Kang, Sora Park, Eun-Young Kim, Byungmi |
author_facet | Kim, Seyoung Park, Eunjung Park, Eun-Kyo Lee, Seulbi Kwon, Jeoung-A Shin, Bo-Hye Kang, Sora Park, Eun-Young Kim, Byungmi |
author_sort | Kim, Seyoung |
collection | PubMed |
description | Bisphenols are endocrine disruptors that may be associated with altered fetal growth in humans, and they have similar biological functions to mimic hormones. In addition, aggregated chemicals showed an adverse effect although individual concentration was at a low level. However, most studies between bisphenols and birth outcomes have focused on the effect of individual bisphenol. Thus, we explored the associations of urinary bisphenol mixtures with birth outcomes. We conducted a prospective birth cohort study in South Korea. One hundred eighty mother-infant pairs were recruited from 2017 to 2019. Bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) in one spot urine were analyzed using ultra-performance liquid chromatography–tandem mass spectrometry. We used two statistical approaches to examine potential associations of BPA, BPF, and BPS with birth weight and gestational age: (1) multivariable linear regression; (2) Bayesian kernel machine regression (BKMR). The geometric means of BPA, BPF, and BPS were 2.1, 0.2, and 0.1 μg/L, respectively. In stratified linear analyses by each median value, a higher BPF was positively associated with birth weight (g) (β = 125.5; 95% CI: 45.0 to 205.9). Mixture analyses using BKMR suggested an inverse association between bisphenol mixtures and birth weight. Our findings suggest that in utero bisphenol exposure may influence birth weight and that such relationships may differ considering non-linearity and the combined effect. |
format | Online Article Text |
id | pubmed-8508042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85080422021-10-13 Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study Kim, Seyoung Park, Eunjung Park, Eun-Kyo Lee, Seulbi Kwon, Jeoung-A Shin, Bo-Hye Kang, Sora Park, Eun-Young Kim, Byungmi Int J Environ Res Public Health Article Bisphenols are endocrine disruptors that may be associated with altered fetal growth in humans, and they have similar biological functions to mimic hormones. In addition, aggregated chemicals showed an adverse effect although individual concentration was at a low level. However, most studies between bisphenols and birth outcomes have focused on the effect of individual bisphenol. Thus, we explored the associations of urinary bisphenol mixtures with birth outcomes. We conducted a prospective birth cohort study in South Korea. One hundred eighty mother-infant pairs were recruited from 2017 to 2019. Bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) in one spot urine were analyzed using ultra-performance liquid chromatography–tandem mass spectrometry. We used two statistical approaches to examine potential associations of BPA, BPF, and BPS with birth weight and gestational age: (1) multivariable linear regression; (2) Bayesian kernel machine regression (BKMR). The geometric means of BPA, BPF, and BPS were 2.1, 0.2, and 0.1 μg/L, respectively. In stratified linear analyses by each median value, a higher BPF was positively associated with birth weight (g) (β = 125.5; 95% CI: 45.0 to 205.9). Mixture analyses using BKMR suggested an inverse association between bisphenol mixtures and birth weight. Our findings suggest that in utero bisphenol exposure may influence birth weight and that such relationships may differ considering non-linearity and the combined effect. MDPI 2021-09-26 /pmc/articles/PMC8508042/ /pubmed/34639400 http://dx.doi.org/10.3390/ijerph181910098 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Seyoung Park, Eunjung Park, Eun-Kyo Lee, Seulbi Kwon, Jeoung-A Shin, Bo-Hye Kang, Sora Park, Eun-Young Kim, Byungmi Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study |
title | Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study |
title_full | Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study |
title_fullStr | Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study |
title_full_unstemmed | Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study |
title_short | Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study |
title_sort | urinary concentrations of bisphenol mixtures during pregnancy and birth outcomes: the make study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508042/ https://www.ncbi.nlm.nih.gov/pubmed/34639400 http://dx.doi.org/10.3390/ijerph181910098 |
work_keys_str_mv | AT kimseyoung urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy AT parkeunjung urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy AT parkeunkyo urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy AT leeseulbi urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy AT kwonjeounga urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy AT shinbohye urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy AT kangsora urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy AT parkeunyoung urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy AT kimbyungmi urinaryconcentrationsofbisphenolmixturesduringpregnancyandbirthoutcomesthemakestudy |