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Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study

Bisphenols are endocrine disruptors that may be associated with altered fetal growth in humans, and they have similar biological functions to mimic hormones. In addition, aggregated chemicals showed an adverse effect although individual concentration was at a low level. However, most studies between...

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Autores principales: Kim, Seyoung, Park, Eunjung, Park, Eun-Kyo, Lee, Seulbi, Kwon, Jeoung-A, Shin, Bo-Hye, Kang, Sora, Park, Eun-Young, Kim, Byungmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508042/
https://www.ncbi.nlm.nih.gov/pubmed/34639400
http://dx.doi.org/10.3390/ijerph181910098
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author Kim, Seyoung
Park, Eunjung
Park, Eun-Kyo
Lee, Seulbi
Kwon, Jeoung-A
Shin, Bo-Hye
Kang, Sora
Park, Eun-Young
Kim, Byungmi
author_facet Kim, Seyoung
Park, Eunjung
Park, Eun-Kyo
Lee, Seulbi
Kwon, Jeoung-A
Shin, Bo-Hye
Kang, Sora
Park, Eun-Young
Kim, Byungmi
author_sort Kim, Seyoung
collection PubMed
description Bisphenols are endocrine disruptors that may be associated with altered fetal growth in humans, and they have similar biological functions to mimic hormones. In addition, aggregated chemicals showed an adverse effect although individual concentration was at a low level. However, most studies between bisphenols and birth outcomes have focused on the effect of individual bisphenol. Thus, we explored the associations of urinary bisphenol mixtures with birth outcomes. We conducted a prospective birth cohort study in South Korea. One hundred eighty mother-infant pairs were recruited from 2017 to 2019. Bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) in one spot urine were analyzed using ultra-performance liquid chromatography–tandem mass spectrometry. We used two statistical approaches to examine potential associations of BPA, BPF, and BPS with birth weight and gestational age: (1) multivariable linear regression; (2) Bayesian kernel machine regression (BKMR). The geometric means of BPA, BPF, and BPS were 2.1, 0.2, and 0.1 μg/L, respectively. In stratified linear analyses by each median value, a higher BPF was positively associated with birth weight (g) (β = 125.5; 95% CI: 45.0 to 205.9). Mixture analyses using BKMR suggested an inverse association between bisphenol mixtures and birth weight. Our findings suggest that in utero bisphenol exposure may influence birth weight and that such relationships may differ considering non-linearity and the combined effect.
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spelling pubmed-85080422021-10-13 Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study Kim, Seyoung Park, Eunjung Park, Eun-Kyo Lee, Seulbi Kwon, Jeoung-A Shin, Bo-Hye Kang, Sora Park, Eun-Young Kim, Byungmi Int J Environ Res Public Health Article Bisphenols are endocrine disruptors that may be associated with altered fetal growth in humans, and they have similar biological functions to mimic hormones. In addition, aggregated chemicals showed an adverse effect although individual concentration was at a low level. However, most studies between bisphenols and birth outcomes have focused on the effect of individual bisphenol. Thus, we explored the associations of urinary bisphenol mixtures with birth outcomes. We conducted a prospective birth cohort study in South Korea. One hundred eighty mother-infant pairs were recruited from 2017 to 2019. Bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) in one spot urine were analyzed using ultra-performance liquid chromatography–tandem mass spectrometry. We used two statistical approaches to examine potential associations of BPA, BPF, and BPS with birth weight and gestational age: (1) multivariable linear regression; (2) Bayesian kernel machine regression (BKMR). The geometric means of BPA, BPF, and BPS were 2.1, 0.2, and 0.1 μg/L, respectively. In stratified linear analyses by each median value, a higher BPF was positively associated with birth weight (g) (β = 125.5; 95% CI: 45.0 to 205.9). Mixture analyses using BKMR suggested an inverse association between bisphenol mixtures and birth weight. Our findings suggest that in utero bisphenol exposure may influence birth weight and that such relationships may differ considering non-linearity and the combined effect. MDPI 2021-09-26 /pmc/articles/PMC8508042/ /pubmed/34639400 http://dx.doi.org/10.3390/ijerph181910098 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Seyoung
Park, Eunjung
Park, Eun-Kyo
Lee, Seulbi
Kwon, Jeoung-A
Shin, Bo-Hye
Kang, Sora
Park, Eun-Young
Kim, Byungmi
Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study
title Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study
title_full Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study
title_fullStr Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study
title_full_unstemmed Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study
title_short Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study
title_sort urinary concentrations of bisphenol mixtures during pregnancy and birth outcomes: the make study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508042/
https://www.ncbi.nlm.nih.gov/pubmed/34639400
http://dx.doi.org/10.3390/ijerph181910098
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