PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells

SIMPLE SUMMARY: TMEPAI/PMEPA1 is known to be highly expressed in various types of cancer, including triple-negative breast cancer (TNBC). Here, we found that TMEPAI-knockout (KO) in TNBC cells showed less tumorigenic abilities and upregulated PHLPP1, which dephosphorylates AKT at Ser473. Additionall...

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Detalles Bibliográficos
Autores principales: Haque, Md. Anwarul, Abdelaziz, Mohammed, Puteri, Meidi Utami, Vo Nguyen, Thanh Thao, Kudo, Kosei, Watanabe, Yukihide, Kato, Mitsuyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508116/
https://www.ncbi.nlm.nih.gov/pubmed/34638419
http://dx.doi.org/10.3390/cancers13194934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508116/
https://www.ncbi.nlm.nih.gov/pubmed/34638419
http://dx.doi.org/10.3390/cancers13194934

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